Oncology Research and Treatment

Original Article · Originalarbeit

Mortality of Patients with Hematological Malignancy after Admission to the Intensive Care Unit

Horster S.a · Stemmler H.J.b · Mandel P.C.a · Mück A.a · Tischer J.b · Hausmann A.b · Parhofer K.G.a · Geiger S.b

Author affiliations

a Medical Department II, b Medical Department III, Intensive Care Unit, Ludwig Maximilian University of Munich, Campus Großhadern, Munich, Germany

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Onkologie 2012;35:556–561

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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: September 18, 2012
Issue release date: October 2012

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT

Abstract

Background: The admission of patients with malignancies to an intensive care unit (ICU) still remains a matter of substantial controversy. The identification of factors that potentially influence the patient outcome can help ICU professionals make appropriate decisions. Patients and Methods: 90 adult patients with hematological malignancy (leukemia 47.8%, high-grade lymphoma 50%) admitted to the ICU were analyzed retrospectively in this single-center study considering numerous variables with regard to their influence on ICU and day-100 mortality. Results: The median simplified acute physiology score (SAPS) II at ICU admission was 55 (ICU survivors 47 vs. 60.5 for non-survivors). The overall ICU mortality rate was 45.6%. With multivariate regression analysis, patients admitted with sepsis and acute respiratory failure had a significantly increased ICU mortality (sepsis odds ratio (OR) 9.12, 95% confidence interval (CI) 1.1– 99.7, p = 0.04; respiratory failure OR 13.72, 95% CI 1.39–136.15, p = 0.025). Additional factors associated with an increased mortality were: high doses of catecholamines (ICU: OR 7.37, p = 0.005; day 100: hazard ratio (HR) 2.96, p < 0.0001), renal replacement therapy (day 100: HR 1.93, p = 0.026), and high SAPS II (ICU: HR 1.05, p = 0.038; day 100: HR 1.2, p = 0.027). Conclusion: The decision for or against ICU admission of patients with hematological diseases should become increasingly independent of the underlying malignant disease.

© 2012 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Article · Originalarbeit

Published online: September 18, 2012
Issue release date: October 2012

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 2296-5270 (Print)
eISSN: 2296-5262 (Online)

For additional information: https://www.karger.com/ORT


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