The Classical Immunosuppression: Overrated or Underused?
Methotrexate: Underused and Ignored?Herfarth H.H. · Long M.D. · Isaacs K.L.
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, N.C., USA
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For more than a decade, methotrexate has been known to be an effective therapeutic agent in the treatment of steroid-dependent active Crohn’s disease. However, international data on medication utilization suggest that this drug is rarely used in clinical practice for an indication of Crohn’s disease. This review investigates the potential reasons for the underuse of methotrexate in patients with inflammatory bowel diseases.
© 2012 S. Karger AG, Basel
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