Antitumor Action of α1-Adrenoceptor Blockers on Human Bladder, Prostate and Renal Cancer CellsGotoh A.a · Nagaya H.a · Kanno T.b · Nishizaki T.b
aLaboratory of Cell and Gene Therapy, Institute for Advanced Medical Sciences, and bDivision of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
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The present study investigated the antitumor action of α1-adrenoceptor blockers on human bladder, prostate and renal cancer cells. For bladder cancer cell lines used here such as 253J, 5637, KK-47, T24 and UM-UC-3 cells, prazosin, a selective α1-adrenoceptor blocker, reduced cell viability at concentrations more than 30 µmol/l. Likewise, naftopidil, a blocker of α1A- and α1D-adrenoceptors, reduced cell viability for all the bladder cancer cells used here in a concentration (10–100 µmol/l)-dependent manner, with a much greater advantage than prazosin. Naftopidil also reduced cell viability for human prostate cancer cell lines such as DU145, LNCap and PC-3 cells and ACHN human renal cancer cells, with a much higher potential than prazosin. Thus, the results of the present study suggest that naftopidil could be a beneficial antitumor drug for the treatment of urological cancers.
© 2012 S. Karger AG, Basel
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