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Short Communication

Antitumor Action of α1-Adrenoceptor Blockers on Human Bladder, Prostate and Renal Cancer Cells

Gotoh A.a · Nagaya H.a · Kanno T.b · Nishizaki T.b

Author affiliations

aLaboratory of Cell and Gene Therapy, Institute for Advanced Medical Sciences, and bDivision of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan

Related Articles for ""

Pharmacology 2012;90:242–246

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: July 12, 2012
Accepted: August 21, 2012
Published online: September 19, 2012
Issue release date: November 2012

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The present study investigated the antitumor action of α1-adrenoceptor blockers on human bladder, prostate and renal cancer cells. For bladder cancer cell lines used here such as 253J, 5637, KK-47, T24 and UM-UC-3 cells, prazosin, a selective α1-adrenoceptor blocker, reduced cell viability at concentrations more than 30 µmol/l. Likewise, naftopidil, a blocker of α1A- and α1D-adrenoceptors, reduced cell viability for all the bladder cancer cells used here in a concentration (10–100 µmol/l)-dependent manner, with a much greater advantage than prazosin. Naftopidil also reduced cell viability for human prostate cancer cell lines such as DU145, LNCap and PC-3 cells and ACHN human renal cancer cells, with a much higher potential than prazosin. Thus, the results of the present study suggest that naftopidil could be a beneficial antitumor drug for the treatment of urological cancers.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: July 12, 2012
Accepted: August 21, 2012
Published online: September 19, 2012
Issue release date: November 2012

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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