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Original Paper

Fluoroquinolone Photodegradation Influences Specific Basophil Activation

Mayorga C.a, b · Andreu I.d · Aranda A.a · Doña I.c · Montañez M.I.a · Blanca-Lopez N.e · Ariza A.a · Nuin E.d · Blanca M.c · Miranda M.A.d · Torres M.J.c

Author affiliations

aResearch Laboratory, bPediatric Service, and cAllergy Service, Carlos Haya Hospital, Malaga, dChemical Technology Institute, UPV-CSIC, Polytechnic University of Valencia, Valencia, and eAllergy Service, Infanta Leonor Hospital, Madrid, Spain

Related Articles for ""

Int Arch Allergy Immunol 2013;160:377–382

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 26, 2012
Accepted: August 27, 2012
Published online: November 22, 2012
Issue release date: March 2013

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Fluoroquinolones (FQs) are photoreactive drugs, but it is not known whether laboratory light exposure can influence the induction of photoproducts and modify in vitro test results. The basophil activation test (BAT) has proven to be useful for evaluating immunoglobulin E (IgE)-mediated hypersensitivity to FQs, with a higher percentage of positive responders with ciprofloxacin (CIP) than with moxifloxacin (MOX). We studied the effect of laboratory light on CIP and MOX degradation, and drug-protein conjugate formation, and its influence on the BAT for evaluating IgE-mediated hypersensitivity to FQs. The results showed an important decrease in fluorescence emission intensity under light compared to dark conditions for MOX, and that BAT positivity was lower in light (17.9%) than in dark (35.7%) conditions. No changes were found for CIP in either fluorescence emission intensity or BAT results (46.4% in both conditions). We can conclude that light exposure is a critical factor in BAT results when photolabile drugs like MOX are used. Therefore, light is important when interpreting in vitro results.

© 2012 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 26, 2012
Accepted: August 27, 2012
Published online: November 22, 2012
Issue release date: March 2013

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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