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Short Communication

Accelerated Up-Dosing of Subcutaneous Immunotherapy with a Registered Allergoid Grass Pollen Preparation

Pfaar O.a · van Twuijver E.c · Hecker H.b · Boot J.D.c · van Ree R.d · Klimek L.a

Author affiliations

aCenter for Rhinology and Allergology Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, and bHAL Allergie GmbH, Düsseldorf, Germany; cHAL Allergy B.V., Leiden, and dDepartment of Experimental Immunology and Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Related Articles for ""

Int Arch Allergy Immunol 2013;160:420–424

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: March 20, 2012
Accepted: August 27, 2012
Published online: November 23, 2012
Issue release date: March 2013

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA

Abstract

Background: Climatic changes causing early pollen flight and new allergens prolonging the pollen season render up-dosing of allergen-specific subcutaneous immunotherapy (SCIT) outside the pollen season considerably more difficult. In addition, for patients with multiple pollen allergies, patients coming near the beginning of pollen season, and patients who wish to up-dose faster, an accelerated induction regimen would be helpful. Methods: In an open, randomized, parallel group, multicenter safety trial, an accelerated up-dosing regimen (0.1–0.3–0.5 ml in weekly intervals) was compared to conventional up-dosing (0.05–0.1–0.2–0.3–0.4–0.5 ml in weekly intervals) with an allergoid grass pollen SCIT preparation. After up-dosing, the maintenance dose was given in monthly intervals. Results: A total of 146 adult patients with rhinitis or rhinoconjunctivitis with or without mild asthma (FEV1 >70%) due to grass pollen were randomized to either the conventional registered up-dosing or an accelerated regimen. In both groups (accelerated regimen, n = 69; conventional regimen, n = 75), a high proportion of patients (92.75 and 92.0%, respectively) successfully reached the maintenance dose without safety concerns. Furthermore, significant increases in specific IgG and IgG4 after 4 months of treatment were observed in both groups. Conclusion: The accelerated SCIT regimen was found to be as safe as the conventional regimen and might be used to up-dose patients within 2 weeks. Moreover, the immunological effects of both up-dosing regimens were comparable.

© 2012 S. Karger AG, Basel


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: March 20, 2012
Accepted: August 27, 2012
Published online: November 23, 2012
Issue release date: March 2013

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: https://www.karger.com/IAA


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