Clinical Translational Research
A and B Blood Group Antigens in Human Pancreatic Ductal AdenocarcinomasHandra-Luca A.
Departments of Pathology, and Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Md., USA; Université Paris 13/Nord Sorbonne Cité APHP, Bobigny, France
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Article / Publication Details
Objectives: The aim of this study was to determine the clinicopathological significance of blood group expression patterns in patients with surgically resected pancreatic ductal adenocarcinomas. Methods: Pancreatic ductal adenocarcinomas from 459 patients were analyzed for immunohistochemical expression of A and B blood group antigens on tissue microarrays. Correlations were established by Fisher’s test, χ2 test, and logistic regression models, and relationships to postsurgical overall survival were analyzed by Kaplan-Meier method, log-rank test, and multivariate Cox models. Results: Tumors expressing blood group A antigen predicted fewer lymph node metastases (<3) and had longer postoperative survival by univariate and multivariate analysis. Loss of A antigen tumor expression in A blood group type patients correlated to vascular invasion. Conclusion: In patients with resectable pancreatic ductal adenocarcinomas, blood group A antigen expression predicted fewer lymph node metastases and was associated with improved outcome after pancreaticoduodenectomy.
© 2012 S. Karger AG, Basel
- Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al: Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 2009;41:986–990.
- Greer JB, Yazer MH, Raval JS, et al: Significant association between ABO blood group and pancreatic cancer. World J Gastroenterol 2010;16:5588–5591.
Bosman FT, Carneiro F, Hruban RH, et al: WHO Classification of Digestive Tumors, ed 4. Lyon, IARC Press, 2010.
- Iodice S, Maisonneuve P, Botteri E, et al: ABO blood group and cancer. Eur J Cancer 2010;46:3345–3350.
- Maisonneuve P, Iodice S, Löhr JM, et al: Re: ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst 2009;101:1156.
- Nakao M, Matsuo K, Hosono S, et al: ABO blood group alleles and the risk of pancreatic cancer in a Japanese population. Cancer Sci 2011;102:1076–7080.
- Saadat M: Re: ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst 2009;101:1285–1286.
- Vioque J, Walker AM: Pancreatic cancer and ABO blood types: a study of cases and controls (in Spanish). Med Clin (Barc) 1991;96:761–764.
- Wolpin BM, Chan AT, Hartge P, et al: ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst 2009;101:424–431.
- Wolpin BM, Kraft P, Xu M, et al: Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium. Cancer Epidemiol Biomarkers Prev 2010;19:3140–3149.
- Hakomori S: Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta 1999;1473:247–266.
- Schuessler MH, Pintado S, Welt S, et al: Blood group and blood-group-related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl-Tn in pancreas cancer. Int J Cancer 1991;47:180–187.
- Ernst C, Thurin J, Atkinson B, et al: Monoclonal antibody localization of A and B isoantigens in normal and malignant fixed human tissues. Am J Pathol 1984;117:451–461.
- Itzkowitz SH, Yuan M, Ferrell LD, et al: Cancer-associated alterations of blood group antigen expression in the human pancreas. J Natl Cancer Inst 1987;79:425–434.
- Pour PM, Tempero MM, Takasaki H, et al: Expression of blood group-related antigens ABH, Lewis A, Lewis B, Lewis X, Lewis Y, and CA 19-9 in pancreatic cancer cells in comparison with the patient’s blood group type. Cancer Res 1988;48:5422–5426.
- Stachura J, Tomaszewska R, Pietroń M: Blood groups antigens distribution in pancreatic cancer. An immunohistochemical study. Folia Histochem Cytobiol 1989;27:49–55.
Takasaki H, Uchida E, Tempero MA, et al: Correlative studies on antigenicity of pancreatic cancer and blood group types. Cancer Detect Prev Suppl 1987;1:145–148.
Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (eds): AJCC Cancer Staging Manual, ed 7. New York, Springer, 2010.
- McShane LM, Altman DG, Sauerbrei W, et al; Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics: Reporting recommendations for neoplastic marker prognostic studies. J Clin Oncol 2005;23:9067–9072.
- Handra-Luca A, Hong SM, Walter K, et al: Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas. Br J Cancer 2011;104:1296–1302.
- Infante JR, Matsubayashi H, Sato N, et al: Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma. J Clin Oncol 2007;25:319–325.
- Davidsohn I, Ni LY, Stejskal R: Tissue isoantigens A, B, and H in carcinoma of the pancreas. Can Res 1971;31:1244–1250.
- Tomioka T, Fujii H, Egami H, et al: Correlation between morphology and blood group-related antigen expression in pancreatic tumors induced in Syrian hamsters. Carcinogenesis 1991;12:441–447.
- Chen CH, Wang PC: Diagnostic plots in Cox’s regression model. Biometrics 1991;47:841–850.
- Christensen E: Multivariate survival analysis using Cox’s regression model. Hepatology 1987;7:1346–1358.
Hosmer DW, Lemeshow S: Applied Logistic Regression, ed 2. New York, Wiley, 2000.
- Ichikawa D, Handa K, Hakomori S: Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human tumor cells as correlated with their malignancy. Int J Cancer 1998;76:284–289.
- Davidsohn I: Early immunologic diagnosis and prognosis of carcinoma. Philip Levine Award Address. Am J Clin Pathol 1972;57:715–730.
- Hirota M, Mogaki M, Pour PM, et al: Modification of blood group A antigen expression in a pancreatic cell line (PC-1) by inhibitors of N-glycam processing. J Cell Biochemistry 1992;50:13–20.
- Pour PM, Uchida E, Burnett DA, et al: Blood-group antigen expression during pancreatic cancer induction in hamsters. Int J Pancreatol 1986;1:327–340.
- Egami H, Tomioka T, Tempero M, et al: Development of intrapancreatic transplantable model of pancreatic duct adenocarcinoma in Syrian golden hamsters. Am J Pathol 1991;138:557–561.
- Greer JB, LaRusch J, Brand RE, et al; NAPS2 Study Group: ABO blood group and chronic pancreatitis risk in the NAPS2 cohort. Pancreas 2011;40:1188–1194.
- Melzer D, Perry JR, Hernandez D, et al: A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 2008;4:e1000072.
- Paré G, Chasman DI, Kellogg M, et al: Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet 2008;4:e1000118.
- Denk H, Tappeiner G, Davidovits A, et al: Carcinoembryonic antigen and blood group substances in carcinomas of the stomach and colon. J Natl Cancer Inst 1974;53:933–942.
- Breimer ME: Tissue specificity of glycosphingolipids as expressed in pancreas and small intestine of blood group A and B human individuals. Arch Biochem Biophys 1984;228:71–85.
- Hakomori S: Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines. Adv Exp Med Biol 2001;491:369–402.
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