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Original Paper

Delayed Cyclic Activity Development on Early Amplitude-Integrated EEG in the Preterm Infant with Brain Lesions

Natalucci G.a, b · Rousson V.c · Bucher H.U.a · Bernet V.c · Hagmann C.a · Latal B.b

Author affiliations

aDepartment of Neonatology, University Hospital, bChild Development Centre and Department of Paediatric Intensive Care and Neonatology, University Children’s Hospital Zurich, Zurich, and cStatistical Unit, Institute for Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland

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Neonatology 2013;103:134–140

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 25, 2012
Accepted: October 17, 2012
Published online: December 01, 2012
Issue release date: February 2013

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: Maturation of amplitude-integrated electroencephalogram (aEEG) activity is influenced by both gestational age (GA) and postmenstrual age. It is not fully known how this process is influenced by cerebral lesions. Objective: To compare early aEEG developmental changes between preterm newborns with different degrees of cerebral lesions on cranial ultrasound (cUS). Methods: Prospective cohort study on preterm newborns with GA <32.0 weeks, undergoing continuous aEEG recording during the first 84 h after birth. aEEG characteristics were qualitatively and quantitatively evaluated using pre-established criteria. Based on cUS findings three groups were formed: normal (n = 78), mild (n = 20), and severe cerebral lesions (n = 6). Linear mixed models for repeated measures were used to analyze aEEG maturational trajectories. Results: 104 newborns with a mean GA (range) 29.5 (24.4–31.7) weeks, and birth weight 1,220 (580–2,020) g were recruited. Newborns with severe brain lesions started with similar aEEG scores and tendentially lower aEEG amplitudes than newborns without brain lesions, and showed a slower development of the cyclic activity (p < 0.001), but a more rapid increase of the maximum and minimum aEEG amplitudes (p = 0.002 and p = 0.04). Conclusions: Preterm infants with severe cerebral lesions manifest a maturational delay in the aEEG cyclic activity already early after birth, but show a catch-up of aEEG amplitudes to that of newborns without cerebral lesions. Changes in the maturational aEEG pattern may be a marker of severe neurological lesions in the preterm infant.

© 2012 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 25, 2012
Accepted: October 17, 2012
Published online: December 01, 2012
Issue release date: February 2013

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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