Relationship between the Phase Angle and Volume of Tumours in Patients with Lung CancerCastanho I.A.a · Lopes A.J.a · Koury J.C.b · Tessarollo B.a · Silva A.C.c · Nunes R.A.a
aUniversity Centre for Cancer Control and bInstitute of Nutrition, State University of Rio de Janeiro, Rio de Janeiro, and cTechnology Centre, Federal University of Maranhão, São Luis, Brazil
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Background/Aims: The phase angle (PA) obtained by bioelectrical impedance has been used as a predictor of nutritional status in cancer. This study aimed to verify the association between the PA and tumour volume in non-small cell lung cancer (NSCLC) patients. Methods: Volumetric determination of the tumour mass was performed using a computerised image analysis system incorporated in helical tomography. Lesion segmentation was performed by a semi-automatic process using a region growth algorithm with voxel aggregation. The PA was measured by bioelectrical impedance. Results: A total of 30 male patients with a mean age of 65.6 years were evaluated. The mean values observed for body mass index, PA and tumour volume were 22.5 ± 4.19, 5.66 ± 0.9° and 163.2 ± 207.5 ml, respectively. The tumour volumes were negatively correlated with the PA (r = –0.55; p < 0.001) and positively correlated with the ratio between the extracellular mass and the body cell mass (ECM/BCM) (r = 0.59; p < 0.001). In multivariate analysis, independent predictors for both PA and ECM/BCM were tumour volume and Karnofsky performance status score. Conclusions: In NSCLC, the PA is closely associated with tumour volume, which may be important in early nutritional intervention.
© 2012 S. Karger AG, Basel
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