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Original Paper

Relationship between the Phase Angle and Volume of Tumours in Patients with Lung Cancer

Castanho I.A.a · Lopes A.J.a · Koury J.C.b · Tessarollo B.a · Silva A.C.c · Nunes R.A.a

Author affiliations

aUniversity Centre for Cancer Control and bInstitute of Nutrition, State University of Rio de Janeiro, Rio de Janeiro, and cTechnology Centre, Federal University of Maranhão, São Luis, Brazil

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Ann Nutr Metab 2013;62:68–74

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 23, 2012
Accepted: November 03, 2012
Published online: December 21, 2012
Issue release date: January 2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

Abstract

Background/Aims: The phase angle (PA) obtained by bioelectrical impedance has been used as a predictor of nutritional status in cancer. This study aimed to verify the association between the PA and tumour volume in non-small cell lung cancer (NSCLC) patients. Methods: Volumetric determination of the tumour mass was performed using a computerised image analysis system incorporated in helical tomography. Lesion segmentation was performed by a semi-automatic process using a region growth algorithm with voxel aggregation. The PA was measured by bioelectrical impedance. Results: A total of 30 male patients with a mean age of 65.6 years were evaluated. The mean values observed for body mass index, PA and tumour volume were 22.5 ± 4.19, 5.66 ± 0.9° and 163.2 ± 207.5 ml, respectively. The tumour volumes were negatively correlated with the PA (r = –0.55; p < 0.001) and positively correlated with the ratio between the extracellular mass and the body cell mass (ECM/BCM) (r = 0.59; p < 0.001). In multivariate analysis, independent predictors for both PA and ECM/BCM were tumour volume and Karnofsky performance status score. Conclusions: In NSCLC, the PA is closely associated with tumour volume, which may be important in early nutritional intervention.

© 2012 S. Karger AG, Basel


References

  1. Lorite MJ, Smith HJ, Arnold JA, Morris A, Trompson MG, Tisdale MJ: Activation of ATP-ubiquitin-dependent proteolysis in skeletal muscle in vivo and murine myoblasts in vitro by a proteolysis-inducing factor (PIF). Br J Cancer 2001;85:297–302.
  2. Barbosa-Silva MCG, Barros AJD, Silva TGB, Larsson E: Reference values for the phase angle in the Brazilian population. RBM 2008;65:104–105.
  3. Barbosa-Silva MC, Barros AJ, Post CL, Waitzberg DL, Heymsfield SB: Can bioelectrical impedance analysis identify malnutrition in preoperative nutrition assessment? Nutrition 2003;19:422–426.
  4. Cox-Reijven PL, van Kreel B, Soeters PB: Bioelectrical impedance measurements in patients with gastrointestinal disease: validation of the spectrum approach and a comparison of different methods for screening for nutritional depletion. Am J Clin Nutr 2003;78:1111–1119.
  5. Gupta D, Lis CG, Dahlk SL, Vashi PG, Grutsch JF, Lammersfeld CA: Bioelectrical impedance phase angle as a prognostic indicator in advanced pancreatic cancer. Br J Nutr 2004;92:957–962.
  6. Piccoli A, Pillon L, Dumler F: Impedance vector distribution by sex, race, body mass index, and age in the United States: standard reference intervals as bivariate Z scores. Nutrition 2002;18:153–167.
  7. Barros JA, Valladares G, Faria AR, Fugita EM, Ruiz AP, Vianna AGD, Trevisan GL, Oliveira FAM: Early diagnosis of lung cancer: the great challenge. Epidemiological variables, clinical variables, staging and treatment. J Bras Pneumol 2006;32:221–227.
  8. Argilés JM: Cancer-associated malnutrition. Eur J Oncol Nurs 2005;9(suppl. 2):S39–S50.
  9. Barbosa-Silva MC, Barros AJ: Bioelectrical impedance analysis in clinical practice: a new perspective on its use beyond body composition equations. Curr Opin Clin Nutr Metab Care 2005;8:311–317.
  10. Piccoli A, Nescolarde LD, Rosell J: Análisis convencional y vectorial de bioimpedancia em la práctica clínica. Nefrología 2002;22:228–238.
  11. Gupta D, Lammersfeld CA, Burrows JL, Dahlk SL, Vashi PG, Grutsch JF, Hoffman S, Lis CG: Bioelectrical impedance phase angle in clinical practice: implications for prognosis in advanced colorectal cancer. Am J Clin Nutr 2004;80:1634–1638.
  12. Toso S, Piccoli A, Gusella M, Menon D, Crepaldi G, Bononi A, Ferrazzi E: Bioimpedance vector pattern in cancer patients without disease versus locally advanced or disseminated disease. Nutr Cancer 2003;19:510–514.
  13. Toso S, Piccoli A, Gusella M, Menon D, Bononi A, Crepaldi G, Ferrazzi E: Altered tissue electric properties in lung cancer patients as detected by bioelectric impedance vector analysis. Nutrition 2000;16:120–124.
  14. Sousa JR, Silva AC, de Paiva AC, Nunes RA: Methodology for automatic detection of lung nodules in computerized tomography images. Comput Methods Programs Biomed 2010;98:1–14.
  15. Silva EC, Silva AC, de Paiva AC, Nunes RA: Diagnosis of lung nodule using Moran’s index and Geary’s coefficient in computerized tomography images. Pattern Anal Applic 2008;11:89–99.
    External Resources
  16. Silva EC, Silva AC, de Paiva AC, Nunes RA, Gattass M: Diagnosis of solitary lung nodules using the local form of Ripley’s K function applied to three-dimensional CT data. Comput Methods Programs Biomed 2008;90:230–239.
  17. Blackburn GL, Bistrian BR: Nutritional and metabolic assessment of the hospitalized patients. J Parenter Enteral Nutr 1977;1:11–22.
  18. Karnofsky DA, Burchenal JH: The clinical evaluation of chemotherapeutic agents in cancer; in MacLeod CM (ed): Evaluation of chemotherapeutic agents. New York, Columbia University Press, 1949, pp 191–205.
  19. Tecnical Report of a WHO Expert Committee: Physical status: the use and interpretation of anthropometry. Geneva, World Health Organization, 1995, vol 854, pp 375–407.
  20. Frisancho AR: New norms of upper limb fat and muscle areas for assessment of nutritional status. Am J Clin Nutr 1981;34:2540–2545.
  21. Barbosa e Silva MCG: Subjective global assessment. Part 1. A review of its validity after two decades of use. Arq Gastroenterol 2002;39:181–187.
  22. Forse RA, Shizgal HM: The assessment of malnutrition. Surgery 1980;88:17–24.
  23. Hopkins B: Assessment of nutritional status; in Gottschlich MM, Matarese LE, Shronts EP (eds): Nutrition Support Dietetics – Core Curriculum. American Society for Parenteral and Enteral Nutrition, ed 2. Maryland, Silver Spring, 1993, pp 15–70.
  24. Uehara C, Santoro IL, Jamnik S: Lung cancer: comparison between sexes. J Pneumol 2000;26:286–290.
    External Resources
  25. El-Torky M, El-Zeky F, Hall JC: Significant changes in the distribution of histologic types of lung cancer. A review of 4928 cases. Cancer 1990;65:2361–2367.
  26. Hoffmann D, Hofmann I: The changing cigarette, 1950–1955. J Toxicol Environ Health 1997;50:307–364.
  27. Wardwell NR, Massion PP: Novel strategies for the early detection and prevention of lung cancer. Semin Oncol 2005;32:259–268.
  28. Mountain CF: Revisions in the International System for Staging Lung Cancer. Chest 1997;111:1710–1717.
  29. Dewys WD, Begg D, Lavin PT: Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med 1980;69:491–497.
  30. Selberg O, Selberg D: Norms and correlates of bioimpedance phase angle in healthy human subjects, hospitalized patients, and patients with liver cirrhosis. Eur J Appl Physiol 2002;86:509–516.
  31. Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, Postmus PE, Rusch V, Sobin L, International Association for the Study of Lung Cancer International Staging Committee, Participating Institutions: The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of Malignant Tumours. J Thorac Oncol 2007;2:706–714.
  32. Liu H, Guo H, Wang Y, Liu R, Chu L, Cui M: Survival and its influencing factors of the lung cancer patients with hospice service. Zhongguo Fei Ai Za Zhi 2012;15:409–415.
    External Resources
  33. Suh SY, Leblanc TW, Shelby RA, Samsa GP, Abernethy AP: Longitudinal patient-reported performance status assessment in the cancer clinic is feasible and prognostic. J Oncol Pract 2011;7:374–381.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 23, 2012
Accepted: November 03, 2012
Published online: December 21, 2012
Issue release date: January 2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM


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