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Original Paper

Effects of Placental Protein 13 on the Cardiovascular System in Gravid and Non-Gravid Rodents

Gizurarson S.a · Huppertz B.c · Osol G.d · Skarphedinsson J.O.b · Mandala M.d, e · Meiri H.f

Author affiliations

aFaculty of Pharmaceutical Sciences, and bInstitute of Physiology, School of Health Science, University of Iceland, Reykjavik, Iceland; cInstitute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria; dDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Burlington, Vt., USA; eDepartment of Cell Biology, University of Calabria, Arcavacata di Rende, Italy; fTelemarpeh Ltd., Tel Aviv, Israel

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Fetal Diagn Ther 2013;33:257-264

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 17, 2012
Accepted: November 18, 2012
Published online: February 08, 2013
Issue release date: May 2013

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT

Abstract

Objectives: Here, we performed a pathophysiological examination of the vascular function of rodent in the presence of placental protein 13 (PP13) and its implication to regulate the development of preeclampsia. Methods: Single i.v. injection and prolonged in vivo exposure to PP13 via osmotic pumps were performed in gravid and non-gravid rats to examine the influence of PP13 on blood pressure and heart rate in animals. The effect of PP13 was also examined in isolated uterine and mesenteric arteries, along with the examination of placental blood supply. Results: Human PP13 has a major impact on the maternal cardiovascular system of rodents by reducing blood pressure, either at single or prolonged exposure, and causing significant vasodilatation in isolated arteries. Prolonged exposure was followed by increased elaboration and angiogenesis of the uteroplacental arteries supplying the placenta. Conclusion: This is the first study describing effects of PP13 on vasodilatation and uterine artery remodeling. The results imply that PP13 may have a physiological role in improving uteroplacental blood flow. The findings of this study make it tempting to speculate that keeping PP13 levels within a certain ‘therapeutic window' during pregnancy may facilitate proper adaptation of the maternal vasculature to pregnancy.

© 2013 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 17, 2012
Accepted: November 18, 2012
Published online: February 08, 2013
Issue release date: May 2013

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: https://www.karger.com/FDT


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