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Brief Communication

Bilirubin Levels and Redox Status in a Young Healthy Population

Rodrigues C.a, d · Rocha S.a, b · Nascimento H.a, b · Vieira E.c · Santos R.c · Santos-Silva A.a, b · Costa E.a, b · Bronze-da-Rocha E.a, b

Author affiliations

aLaboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia and bInstituto de Biologia Molecular e Celular, Universidade do Porto, and cUnidade de Genética Molecular, Centro de Genética Médica Dr. Jacinto Magalhães INSARJ, Porto, and dDepartamento das Tecnologias de Diagnóstico e Terapêutica, Escola Superior de Saúde, Instituto Politécnico de Bragança, Bragança, Portugal

Related Articles for ""

Acta Haematol 2013;130:57-60

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Article / Publication Details

Received: August 27, 2012
Accepted: November 21, 2012
Published online: March 06, 2013
Issue release date: June 2013

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


First-Page Preview
Abstract of Brief Communication

References

  1. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, Lindhout D, Tytgat GN, Jansen PL, Oude Elferink RP, Chowdhury NR: The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med 1995;333:1171-1175.
  2. Bulmer AC, Blanchfield JT, Toth I, Fassett RG, Coornbes JS: Improved resistance to serum oxidation in Gilbert's syndrome: a mechanism for cardiovascular protection. Atherosclerosis 2008;199:390-396.
  3. Brito A, Silva RF, Brites D: Bilirubin induces loss of membrane lipids and exposure of phosphatidylserine in human erythrocytes. Cell Biol Toxicol 2002;18:181-192.
  4. Gopinathan V, Miller NJ, Milner AD, Rice-Evans CA: Bilirubin and ascorbate antioxidant activity in neonatal plasma. FEBS Lett 1994;349:197-200.
  5. Arese P, Turrini F, Schwarzer E: Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes. Cell Physiol Biochem 2005;16:133-146.
  6. Costa E, Rocha S, Rocha-Pereira P, Castro E, Miranda V, Sameiro-Faria S, Loureiro A, Quintanilha A, Belo L, Santos-Silva A: Band 3 profile as a marker of erythrocyte changes in chronic kidney disease patients. Open Clin Chem J 2008;1:57-63.
  7. Costa E, Vieira E, Dos Santos R: The polymorphism c.-3279T>G in the phenobarbital-responsive enhancer module of the bilirubin UDP-glucuronosyltransferase gene is associated with Gilbert syndrome. Clin Chem 2005;51:2204-2206.
  8. Boon AC, Hawkins CL, Bisht K, Coombes JS, Bakrania B, Wagner KH, Bulmer AC: Reduced circulating LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radic Biol Med 2012;52:2120-2127.
  9. Rodrigues C, Costa E, Vieira E, Carvalho J, Santos R, Rocha-Pereira P, Santos-Silva A, Bonze-da-Rocha E: Bilirubin is mainly dependent on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index. Am J Med Sci 2012;343:114-118.
  10. Buyukasik Y, Akman U, Buyukasik NS, Goker H, Kilicarslan A, Shorbagi AI, Hascelik G, Haznedaroglu IC: Evidence for higher red blood cell mass in persons with unconjugated hyperbilirubinemia and Gilbert's syndrome. Am J Med Sci 2008;335:115-119.

Article / Publication Details

Received: August 27, 2012
Accepted: November 21, 2012
Published online: March 06, 2013
Issue release date: June 2013

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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