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Case Report

Precursor B-Cell Lymphoblastic Leukemia with Surface Immunoglobulin Light Chain Expression in 2 Chinese Patients

Liu Y. · Zhai Y. · Zhang Y. · Cheng W. · Li Y.

Author affiliations

Hematology Department, Henan Provincial People's Hospital, The People's Hospital of Zhengzhou University, Zhengzhou, China

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Acta Haematol 2013;130:188-191

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: June 18, 2012
Accepted: January 04, 2013
Published online: June 11, 2013
Issue release date: September 2013

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

Background: Precursor B-cell acute lymphocytic leukemia (ALL) with surface immunoglobulin light chain expression is a rare disease entity. The differential diagnosis is difficult but critical for disease management. Aims: We report 2 cases (1 adult and 1 infant) of precursor B-cell ALL who presented at diagnosis with surface immunoglobulin light chain expression revealed by flow cytometric immunophenotyping and discuss its clinical significance. Case Report: The 2 patients presented with nonspecific symptoms such as fever, pallor, fatigue or lymphadenopathy. Flow cytometric immunophenotyping showed that both patients expressed CD34/CD19/CD10/CD22/CD9/HLA-DR/CD38/CD123/CD13 (partial) and had unexpected single λ light chain expression. Cytogenetic analysis revealed t(9;22)(q34;q11) in the adult patient and normal karyotype in the infant. Both cases were diagnosed and managed as precursor B-ALL, and the patients showed good response to treatment regimens. Conclusion: We describe 2 cases of precursor B-ALL with unexpected surface light chain expression. The exceedingly rare immunophenotypes have diagnostic implication for immunophenotyping of this malignancy. Treatment regimens for precursor B-cell ALL are suitable for such cases.

© 2013 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: June 18, 2012
Accepted: January 04, 2013
Published online: June 11, 2013
Issue release date: September 2013

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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