Dermatology
Original Paper
Androgenic Hormone Profile of Adult Women with Acneda Cunha M.G.a · Fonseca F.L.A.b, d · Machado C.D.A.S.caAcne Ambulatory Clinic of the Dermatology Discipline, bClinical Analysis Laboratory and cDermatology Department, ABC Medical School, Santo André, and dFederal University of São Paulo, São Paulo, Brazil
Keywords: WomenAcneAndrogenic hormones |
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Article / Publication Details
Received: June 01, 2012
Accepted: January 16, 2013
Published online: May 16, 2013
Issue release date: June 2013
Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 3
ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)
For additional information: https://www.karger.com/DRM
Abstract
Acne in adult women is a hard-to-manage frequent disease with many relapse cases. It mostly interferes with quality of life and causes major social and metabolic losses for patients. This is a transversal retrospective study and the aim was to standardize the research on circulating androgenic hormone levels and to detect hyperandrogenic states early, showing the frequency and the pattern of the altered hormones, useful resources to correctly evaluate each patient. In this study 835 women above 15 years of age, with acne or aggravation cases, were analyzed. The aim was to verify the percentage of androgen examinations with levels above normal. The levels of the hormones dehydroepiandrosterone sulfate, dehydroepiandrosterone (DHEA), dehydrotestosterone, androstenedione and total testosterone were measured in all patients. The evaluation of the hormone profile showed that 54.56% of the patients had hyperandrogenism, and the levels of DHEA were most frequently elevated. Therefore, in the face of the importance of hyperandrogenism in the pathogenesis of acne, standardizing the research of the hormone profile is paramount for the treatment and control of relapses in case of a surge of acne breakouts during a woman's adult life.
© 2013 S. Karger AG, Basel
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References
- Perkins AC, Maglione J, Hillebrand GG, Myamoto K, Kimball AB: Acne vulgaris in women: prevalence across the life span. J Womens Health 2012;21:223-230.
- Preneau S, Dreno B: Female acne - a different subtype of teenager acne? J Eur Acad Dermatol Venereol 2012;26:277-282.
- Azziz R, Sanchez A, Knochenhauer ES, Moran C, Lazenby J, Stephens KC, et al: Extensive personal experience - androgen excess in women: experience with over 1,000 consecutive patients. J Clin Endocrinol Metab 2004;89:453-462.
- Clarke SB, Nelson AM, George RE, Thiboutot DM: Pharmacologic modulation of sebaceous gland activity: mechanisms and clinic applications. Dermatol Clin 2007;25:137-146.
- Strauss JS, Krowchuk DP, Leyden JJ, Lucky AW, Shalita AR, Siegfried EC: Guidelines of care for acne vulgaris management. J Am Acad Dermatol 2007;56:651-663.
- Zouboulis CC, Eady A, Philpott M, Goldsmith LA, Orfanos C, Cunliffe WC, Rosenfield R: What is the pathogenesis of acne? Exp Dermatol 2005;14:143-152.
- Smith KJ, Dipreta E, Skelton H: Peroxisomes in dermatology. Part I. J Cutan Med Surg 2001;5:231-243.
- Downie MM, Sanders DA, Maier LM, Stock DM, Kealey T: Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. Br J Dermatol 2004;151:766-775.
- Kurokawa I, Danby FW, Ju Q, et al: New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 2009;18:821-832.
- Thiboutot D: Acne: hormonal concepts and therapy. Clin Dermatol 2004;22:419-428.
- Shaw JC: Acne: effect of hormones on pathogenesis and management. Am J Clin Dermatol 2002;3:571-578.
- Karrer-Voegeli S, Rey F: Androgen dependence of hirsutism, acne and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism. Medicine 2009;88:32-45.
- Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 2012;97:28-38.
- Timpatanapong P, Rojanasakul A: Hormonal profiles and prevalence of PCOS in women with acne. J Dermatol 1997;24:223-229.
- Huang A, Brennan K, Azziz R: Prevalence of hyperandrogenemia in the polycystic ovary syndrome diagnosed by NIH 1990 criteria. Fertil Steril 2010;93:1938-1941.
- Borgia F, Cannavò S, Guarnieri F, Cannavò SP, Vaccaro M, Guarnieri B: Correlation between endocrinological parameters and acne severity in adult women. Acta Derm Venereol 2004;84:201-204.
- Slayden S, Moran C: Hyperandrogenemia in patients presenting with acne. Fertil Steril 2001;75:889-891.
- Cho WL, Kilpatrick E, Jayagopal V, Diver MJ, Atkin SL: Biological variation of total testosterone, free androgen index and bioavailable testosterone in polycystic ovarian syndrome: implications for identifying hyperandrogenemia. Clin Endocrinol 2008;68:390-394.
- Williams C, Layton AM: Persistent acne in women: implications for the patient and for therapy. Am J Clin Dermatol 2006;7:281-290.
- Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;81:19-25.
- Bronstein J, Tawdekar S, Liu Y, Pawelczak M, David R, Shah B: Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought. J Pediatr Adolesc Gynecol 2011;24:15-20.
- Bumbuliene Z, Alisauskas J: Evaluation and treatment of adolescent girls with hirsutism. Ginekol Pol 2009;80:374-378.
- Hickey M, Doherty DA, Atkinson H, Sloboda DM, Franks S, Norman RJ, Hart R: Clinic, ultrasound and biochemical features of polycystic ovary syndrome in adolescents: implications for diagnosis. Hum Reprod 2011;26:1469-1477.
- Rackow BW: Polycystic ovary syndrome in adolescents. Curr Opin Obstet Gynecol 2012;24:281-287.
- Reyss AC, Proust-Richard C, Catteau-Jonard S, Dewailly D: Rotterdam consensus in adolescent girls: which investigations and how to interpret them to make the diagnosis of PCOS? Gynecol Obstet Fertil 2006;34:341-346.
- Rosenfield RL: Hyperandrogenism in peripubertal girls. Pediatr Clin North Am 1990;37:1333-1358.
- Glueck CJ, Morrison JA, Daniels S, Wang P, Stroop D: Sex hormone-binding globulin, oligomenorrhea, polycystic ovary syndrome, and childhood insulin at age 14 years predict metabolic syndrome and class III obesity at age 24 years. J Pediatr 2011;159:308-313.
- Rosenfield RL, Lucky AW: Acne, hirsutism, and alopecia in adolescent girls. Clinical expressions of androgen excess. Endocrinol Metab Clin North Am 1993;22:507-532.
- Chanukvadze D, Kristesashvili J: Effectiveness of different diagnostic methods for assessment of hyperandrogenism in young women with hirsutism. Georgian Med News 2011;11:25-29.
- Shannon M, Wang Y: Polycystic ovary syndrome: a common but often unrecognized condition. J Midwifery Womens Health 2012;57:221-230.
- Catteau-Jonard S, Cortet-Rudelli C, Richard-Proust C, Dewailly D: Hyperandrogenism in adolescent girls. Endocr Dev 2012;22:181-193.
- Melnik B: Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies. J Dtsch Dermatol Ges 2009;7:364-370.
- Melnik BC: Evidence for acne-promoting effects of milk and other insulinotropic dairy products. Nestle Nutr Workshop Ser Pediatr Program 2011;67:131-145.
Article / Publication Details
Received: June 01, 2012
Accepted: January 16, 2013
Published online: May 16, 2013
Issue release date: June 2013
Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 3
ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)
For additional information: https://www.karger.com/DRM
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