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Original Paper

Effects of Fluoride on in vitro Enamel Demineralization Analyzed by 19F MAS-NMR

Mohammed N.R.a · Kent N.W.a · Lynch R.J.M.b · Karpukhina N.a · Hill R.a · Anderson P.a

Author affiliations

aDental Physical Sciences Unit, Centre for Oral Growth and Development, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, and bGlaxoSmithKline Consumer Healthcare, Weybridge, UK

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Caries Res 2013;47:421-428

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 11, 2012
Accepted: February 23, 2013
Published online: May 23, 2013
Issue release date: September 2013

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE

Abstract

The mechanistic action of fluoride on inhibition of enamel demineralization was investigated using 19F magic angle spinning nuclear magnetic resonance (MAS-NMR). The aim of this study was to monitor the fluoride-mineral phase formed on the enamel as a function of the concentration of fluoride ions [F-] in the demineralizing medium. The secondary aim was to investigate fluorapatite formation on enamel in the mechanism of fluoride anti-caries efficacy. Enamel blocks were immersed into demineralization solutions of 0.1 M acetic acid (pH 4) with increasing concentrations of fluoride up to 2,262 ppm. At and below 45 ppm [F-] in the solution, 19F MAS-NMR showed fluoride-substituted apatite formation, and above 45 ppm, calcium fluoride (CaF2) formed in increasing proportions. Further increases in [F-] caused no further reduction in demineralization, but increased the proportion of CaF2 formed. Additionally, the combined effect of strontium and fluoride on enamel demineralization was also investigated using 19F MAS-NMR. The presence of 43 ppm [Sr2+] in addition to 45 ppm [F-] increases the fraction of fluoride-substituted apatite, but delays formation of CaF2 when compared to the demineralization of enamel in fluoride-only solution.

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 11, 2012
Accepted: February 23, 2013
Published online: May 23, 2013
Issue release date: September 2013

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 1

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE


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