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Neuronal Mechanisms and the Treatment of Motion Sickness

Schmäl F.

Author affiliations

Department of Otorhinolaryngology, Head and Neck Surgery, HNO-Zentrum Münsterland, Greven, Germany

Corresponding Author

Prof. Dr. Frank Schmäl

HNO-Zentrum Münsterland

Lindenstrasse 37

DE-48268 Greven (Germany)

E-Mail schmael.hno@web.de

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Pharmacology 2013;91:229-241

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The aim of this review is to provide an overview of the physiological basis, clinical picture and treatment options for motion sickness. Motion sickness is a well-known nausea and vomiting syndrome in otherwise healthy people. The physical signs of motion sickness occur in both humans and animals during travel by sea, automobile or airplane and in space. Furthermore, some other special situations, such as simulators, the cinema and video games, have been described as causing pseudomotion sickness. Children between 2 and 12 years old are most susceptible to motion sickness, and women are more frequently affected than men. Predisposing factors include menstruation, pregnancy, migraines and possibly a side difference in the mass of otoconia in the vestibular organs. Therapy is directed towards decreasing conflicting sensory input, accelerating the process of adaptation and controlling nausea and vomiting. To control these vegetative symptoms, scopolamine and antihistamines are the most effective drugs.

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Article / Publication Details

Received: February 11, 2013
Accepted: February 12, 2013
Published online: April 20, 2013
Issue release date: May 2013

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

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