Pharmacology

Original Paper

Mechanisms of the Protective Effects of Curcumin against Indomethacin-Induced Gastric Ulcer in Rats

Morsy M.A.a, b · El-Moselhy M.A.c

Author affiliations

aDepartment of Pharmaceutical Sciences/Pharmacology Division, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; bDepartment of Pharmacology, Faculty of Medicine, and cDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt

Keywords: CurcuminGastric ulcerInducible nitric oxide synthaseNuclear factor-κBCaspase-3

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Pharmacology 2013;91:267-274
https://doi.org/10.1159/000350190

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 26, 2012
Accepted: February 20, 2013
Published online: May 15, 2013
Issue release date: July 2013

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

Background/Aims: Curcumin, a naturally occurring polyphenolic compound, exhibits anti-inflammatory and antioxidant properties that render it an attractive candidate for protection against gastric ulcer. The aim of this study is therefore to evaluate the protective effects of curcumin against indomethacin-induced gastric ulcer in rats. Methods: Gastric ulceration was induced by a single intraperitoneal injection of indomethacin (30 mg/kg). Curcumin (50 mg/kg, p.o.) was administered 30 min before ulcer induction. Results: Curcumin showed gastroprotective effects as evidenced by significant decreases in ulcer index, total acid output and pepsin activity in gastric juice in addition to gastric mucosal malondialdehyde concentration, and concomitant increases in gastric juice mucin concentration, gastric mucosal nitric oxide level and catalase and superoxide dismutase activities as compared to the indomethacin-induced ulcer group. Moreover, immunohistochemical investigations demonstrated that curcumin treatment markedly decreased expression of inducible nitric oxide synthase, nuclear factor-κB, and caspase-3. Conclusion: Curcumin protected the rats' gastric mucosa against indomethacin-induced gastric ulceration possibly, at least in part, by enhancement of the gastric mucosal barrier and reduction in acid secretory parameters in addition to antioxidant and antiapoptotic activities.

© 2013 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 26, 2012
Accepted: February 20, 2013
Published online: May 15, 2013
Issue release date: July 2013

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

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