Cardiology
Original Research
Low-Dose Furosemide Administered with Adequate Hydration Reduces Contrast-Induced Nephropathy in Patients Undergoing Coronary AngiographyGu G.-Q. · Lu R. · Cui W. · Liu F. · Zhang Y. · Yang X.-H. · Chen X.-F. · Jia W.-M.Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang, China
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Article / Publication Details
Received: November 29, 2012
Accepted: March 05, 2013
Published online: May 07, 2013
Issue release date: June 2013
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Abstract
Objective: We investigated the effects of low-dose furosemide, administered with adequate hydration on contrast-induced nephropathy (CIN). Methods: A total of 859 patients scheduled to undergo coronary angiography or angioplasty were enrolled and randomly assigned to a furosemide treatment or control group. All patients received supplemental hydration. Immediately after surgery, patients in the furosemide group received intravenous furosemide injection (20 mg); those in the control group received no treatment. Total fluid intake and urine output were recorded. Pre- and postsurgical changes in serum creatinine levels (SCr), glomerular filtration rate (GFR) and creatinine clearance rate (CCr) were assessed, and the incidence of CIN was also evaluated between the two groups. Logistic regression analysis was used to study risk factors for CIN. Results: General baseline conditions were similar between the two groups. Patients who received furosemide had significantly less increase in SCr and a more marked increase in GFR and CCr than those who did not. The incidence of CIN was significantly higher in the control group. Logistic regression analysis revealed that female gender and angiotensin-converting enzyme inhibitor were risk factors for CIN, whereas furosemide acted as a protective agent. Conclusions: With full hydration, small doses of furosemide can reduce CIN better than hydration alone.
© 2013 S. Karger AG, Basel
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References
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Article / Publication Details
Received: November 29, 2012
Accepted: March 05, 2013
Published online: May 07, 2013
Issue release date: June 2013
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 4
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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