European Neurology
Original Paper
Microbleed Burden and Hematoma Expansion in Acute Intracerebral HemorrhageMartí-Fàbregas J.a · Delgado-Mederos R.a · Granell E.b · Morenas Rodríguez E.a · Marín Lahoz J.a · Dinia L.a · Carrera D.a · Pérez de la Ossa N.c · Sanahuja J.d · Sobrino T.e · De Arce A.M.f · Alonso de Leciñana M.g · on behalf of the RENEVAS group (Stroke Research Network, RETICS, Instituto de Salud Carlos III)Departments of aNeurology and bRadiology, Hospital de la Santa Creu i Sant Pau (IIb Sant Pau), Barcelona, cDepartment of Neurology, Hospital Germans Trias i Pujol, Badalona, dDepartment of Neurology, Hospital Arnau de Vilanova, Lleida, eClinical Neurosciences Research Laboratory, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, fDepartment of Neurology, Hospital de Donostia, Donostia, and gDepartment of Neurology, Hospital Ramón y Cajal, Madrid, Spain
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Article / Publication Details
Received: January 22, 2013
Accepted: April 08, 2013
Published online: August 06, 2013
Issue release date: October 2013
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Abstract
Background: Intracranial amyloid and hypertensive angiopathy have been related to impaired blood vessel function and the etiology of intracerebral hemorrhage (ICH). Microbleeds (MBs) are surrogate radiological markers that are associated with these underlying angiopathies. We assessed the hypothesis that MBs are associated with hematoma expansion (HE) in patients with hyperacute ICH. Methods: We studied patients with spontaneous supratentorial ICH within the first 6 h after onset. HE was defined as an increase ≥33% in the volume of hematoma on the follow-up CT in comparison with the admission CT. The volume was calculated using the ABC/2 formula. MBs were detected by specific magnetic resonance sequences (gradient-echo). The presence, number and distribution of MBs were analyzed. Results: Our study included 44 patients. Their mean age was 68.9 ± 11.1 years, and 70.5% of them were men. HE was observed in 14 of the patients (31.8%). HE was more prevalent in patients with more than 10 MBs compared with patients with 1-10 MBs (60 vs 12.5%; p = 0.03). Conclusion: A high burden of MBs is associated with an increased risk of HE in patients with ICH. This is probably a marker of a more severe underlying angiopathy.
© 2013 S. Karger AG, Basel
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Article / Publication Details
Received: January 22, 2013
Accepted: April 08, 2013
Published online: August 06, 2013
Issue release date: October 2013
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
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