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Original Article · Originalarbeit

Relationship between Adiponectin and Leptin, and Blood Lipids in Hyperlipidemia Patients Treated with Red Yeast Rice

Lee C.-Y.a, b · Jan M.-S.c · Yu M.-C.a,d,e · Lin C.-C.a, f · Wei J.C.-C.a,d,g · Shih H.-C.a, b

Author affiliations

a Institute of Medicine, Chung Shan Medical University, b Department of Pharmacy, c Graduate Institute of Applied Medical Microbiology, d Department of Internal Medicine, e Department of Integrated Chinese and Western Medicine, f Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, g Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan

Keywords: LeptinRed yeast riceLow-density lipoprotein cholesterolLDL-CHigh-density lipoprotein cholesterolHDL-CAdiponectin

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Forsch Komplementmed 2013;20:197-203
https://doi.org/10.1159/000351455

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Article / Publication Details

First-Page Preview
Abstract of Original Article <i>· </i> Originalarbeit

Published online: June 20, 2013
Issue release date: July 2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: https://www.karger.com/CMR

Abstract

Background: This study aimed to investigate the possible relationships between adiponectin and leptin, blood lipids such as total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) as well as other clinical biomarkers in hyperlipidemia patients treated with red yeast rice. Methods: 30 patients with primary hyperlipidemia were recruited, treated with red rice yeast capsules 600 mg twice a day for 8 weeks, and followed up for 4 weeks. The primary endpoint was the mean difference in LDL-C from baseline to week 8, while the secondary endpoints were the mean percentage changes from baseline of total cholesterol, TG, HDL-C, adiponectin, and leptin. Results: At week 8, the decrease in LDL-C and total cholesterol was -38.11 ± 30.90 mg/dl (p < 0.0001) and -44.54 ± 27.46 mg/dl (p < 0.0001), respectively, and the increase in adiponectin was 35.83 ± 67.85 μg/ml (p = 0.017) as compared to baseline. Adiponectin also correlated positively with HDL-C (r2 = 0.39; p = 0.001). Serum leptin correlated negatively with TG (r2 = 0.19; p = 0.035), and there was a trend of correlation between leptin and HDL-C, but this was not statistically significant (r2 = 0.16; p = 0.052). Conclusion: Red yeast rice can significantly increase adiponectin and can significantly lower LDL-C and total cholesterol levels. Adiponectin correlates positively with HDL-C while serum leptin correlates negatively with TG. Red yeast rice has a potentially protective effect in obesity-related and cardiovascular diseases.

© 2013 S. Karger GmbH, Freiburg



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Article / Publication Details

First-Page Preview
Abstract of Original Article <i>· </i> Originalarbeit

Published online: June 20, 2013
Issue release date: July 2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 2504-2092 (Print)
eISSN: 2504-2106 (Online)

For additional information: https://www.karger.com/CMR

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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