Original Paper
Myogenic Oscillations in Rabbit Ocular Vasculature Are Very Low FrequencyDelgado E.a · Marques-Neves C.b · Rocha I.b · Sales-Luís J.a · Silva-Carvalho L.baDepartamento de Clínica, Centro de Investigação Interdisciplinar em Sanidade Animal, Faculty of Veterinary Medicine, Lisbon Technical University and bInstituto de Medicina Molecular and Instituto de Fisiologia, Faculty of Medicine, Lisbon University, Lisbon, Portugal
|
|
Ophthalmic Res 2013;50:123-128
Do you have an account?
To view the fulltext, please log in
To view the pdf, please log in
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
* The final prices may differ from the prices shown due to specifics of VAT rules.
Article / Publication Details
First-Page Preview
Received: November 26, 2012
Accepted: March 20, 2013
Published online: July 27, 2013
Issue release date: August 2013
Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0
ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)
For additional information: https://www.karger.com/ORE
Abstract
Background/Aims: In a previously described model of isolated rabbit eye, we detected myogenic intrinsic vascular tone of unknown origin in the ophthalmic artery. In order to better understand the origin of these low frequency oscillations, we analyzed their spectral characteristics using fast Fourier. Methods: Hybrid New Zealand rabbits of either sex (n = 24) were used; they were divided into 2 groups according to age. The spectral characteristics of the myogenic behaviour of the rabbit external ophthalmic artery were analyzed using the fast Fourier algorithm. Results: The frequency of the oscillations of the myogenic activity seen in the rabbit external ophthalmic artery varied between 0.033 and 0.066 Hz (mean 0.045 ± 0.012 Hz), all in the region of very low frequency (VLF) oscillations (VLF <0.07 Hz for the rabbit). The frequency of spontaneous oscillations was higher in younger animals. Conclusion: Fast Fourier analysis proved to be an adequate mathematical tool to analyze the myogenic tone oscillations, which were all in the range of VLF in the model we used. These results indicate that myogenic vascular function of ocular blood flow is composed of VLF oscillations, and they provide a new explanation for the origin of VLF in arterial spectra. They also suggest that the ocular local myogenic vascular function observed is more efficient in younger animals.
© 2013 S. Karger AG, Basel
Related Articles:
References
- Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology: Heart rate variability. Standards of measurement, physiological interpretation and clinical use. Circulation 1996;93:1043-1065.
-
Cerruti S, Binachi AM, Mainard LT: Spectral analysis of the heart rate variability signal; in Malik M, Camm AJ (eds): Heart Rate Variability. New York, Futura Publishing Company, 1995, pp 63-76.
- Parati G, Saul JP, Di Rienzo M, Mancia M: Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation. A critical appraisal. Hypertension 1995;25:1276-1286.
-
Rocha I, Gonçalves V, Escalda A, Laranjo S Ducla-Soares E, Andrade A, Boto JP, Silva-Carvalho L: Effect of stimulation of the cerebelar cortex on autonomic efferences. CAR 2006;16:181.
- Daffonchio A, Franzelli C, Di Rienzo M, Castiglioni P, Ramirez A, Parati G, Mancia G, Ferrari A: (1991) Effects of sympathectomy on blood pressure variability in the conscious rat. J Hypertens suppl 1991;9:S70-S71.
- Langager AM, Hammerberg BE, Rotella DL, Stauss HM: Very low-frequency blood pressure variability depends on voltage-gated L-type Ca2+ channels in conscious rats. Am J Physiol Heart Circ Physiol 2007;292:H1321-H1327.
- Malliani A, Pagani M, Lombardi F, Cerutti S: Cardiovascular neural regulation explored in the frequency domain. Circ 1991;84:482-492.
- Saul J, Rea R, Eckberg D, Berger R, Cohen R: Heat rate and muscle sympathetic nerve variability during reflex changes of autonomic activity. Am J Physiol 1990;258:H713-H721.
- Vigo D, Guinjoan S, Scaramal M, Sitri L, Cardinali D: Wavelet transform shows age-related changes of heart rate variability within independent frequency components. Auton Neurosci 2005;123:94-100.
- Pichot V, Buffière S, Gaspoz J, Costes F, Molliex S, Duverney D, Roche F, Barthélémy J: Wavelet transform of heart rate variability to assess autonomic nervous system activity does not predict arousal from general anaesthesia. Can J Anesth 2001;48:859-863.
- Ponikowski P, Chua TP, Piepoli M, Amadi AA, Harrington D, Webb-Peploe K, Volterrani M, Colombo R, Mazzuero G, Giordano A, Coats AJ: Chemoreceptor dependence of very low frequency rhythms in advanced chronic heart failure. Am J Physiol 1997;272:H438-H447.
- Stauss HM, Rarick KR, Deklotz RJ, Sheriff DD: Frequency response characteristics of whole body autoregulation of blood flow in rats. Am J Physiol Heart Circ Physiol 2009;296:H1607-H1616.
- Delgado E, Marques-Neves C, Rocha I, Sales-Luis J, Silva-Carvalho L: Endothelin-1 effects on spontaneous oscillations in choroidal arterioles. Acta Ophthalmol 2010a;88:742-747.
- Delgado E, Marques-Neves C, Rocha I, Sales-Luis J, Silva-Carvalho L: L-Arg and L-NAME effects on vasomotion in isolated rabbit eyes. Ophthalmic Res 2010;43:113-121.
- Delgado E, Marques-Neves C, Rocha I, Sales-Luis J, Silva-Carvalho L: Amlodipine effects on arterial vasomotion in an isolated rabbit eye. Graefe's Arch Clin Exp Ophthalmol 2010c;248:213-221.
- Braun RD, Linsenmeier RA, Yancey CM: Spontaneous fluctuations in oxygen tension in the cat retina. Microvasc Res 1992;44:73-84.
- Buerk DG, Riva CE: Vasomotion and spontaneous low-frequency oscillations in blood flow and nitric oxide in cat optic nerve head. Microvasc Res 1998;55:103-112.
- Hoste A, Boels P, Brutsaert D, De Laey J: Effect of alpha-1 and beta agonists on contraction of bovine retinal resistance arteries in vitro. Invest Ophthalmol Vis Sci 1989;30:44-50.
- Nyborg N, Korsgaard N, Nielsen P: Active wall tension-length curve and morphology of isolated bovine retinal small arteries: important feature for pharmacodynamic studies. Invest Ophthalmol Vis Sci 1990;51:217-224.
- Yu D, Alder V, Cringle S, Su E, Yu P: Vasoactivity of intraluminal and extraluminal agonists in perfused retinal arteries. Invest Ophthalmol Vis Sci 1994;35:4087-4099.
- Jeppesen P, Aalkjaer C, Bek T: Myogenic response in isolated porcine retinal arterioles. Curr Eye Res 2003;27:217-222.
- Hessellund A, Jeppesen P, Aalkjaer C, Bek T: Characterization of vasomotion in porcine retinal arterioles. Acta Ophthalmol Scand 2003;81:278-282.
- Hessellund A, Aalkjaer C, Bek T: Effect of cyclic guanosine-monophosphate on porcine retinal vasomotion. Acta Ophthalmol Scand 2006;84:228-233.
- Delaey C, Van de Voorde J: Pressure-induced myogenic responses in isolated bovine retinal arteries. Invest Ophthalmol Vis Sci 2000;41:1871-1875.
- Jarajapu Y, Grant M, Knot H: Myogenic tone and reactivity of the rat ophthalmic artery. Invest Ophthalmol Vis Sci 2004;45:253-259.
- Krejcy K, Wolzt M, Kreuzer C, Breiteneder H, Schutz W, Eichler HG, Schmetterer L: Characterization of angiotensin-II effects on cerebral and ocular circulation by noninvasive methods. Brit J Clin Pharmacol 1997;43:501-508.
- Yu D, Su E, Cringle S, Yu P: Isolated preparations of ocular vasculature and their applications in ophthalmic research. Prog Retin Eye Res 2003;22:135-169.
- Ito I, Jarajapu Y, Guberski D, Grant M, Knot H: Myogenic tone and reactivity of rat ophthalmic artery in acute exposure to high glucose and in a type II diabetic model. Invest Ophthalmol Vis Sci 2006;47:683-692.
- Kiel J: Modulation of choroidal autoregulation in the rabbit. Exp Eye Res 1999;69:413-429.
- Kolb B, Rotella DL, Stauss HM: Frequency response characteristics of cerebral blood flow autoregulation in rats. Am J Physiol Heart Circ Physiol 2007;292:H432-H438.
- Stauss HM: Identification of blood pressure control mechanisms by power spectral analysis. Clin Exp Pharmacol Physiol 2007;34:362-368.
- Fleĭshman AN, Filimonov SN, Klimina NV: The novel method for selection of preparations for treatment of arterial hypertension based on spectral analysis of heart rhythm variability. Ter Arkh 2001;73:33-39.
- Zamir M, Goswami R, Liu L, Salmanpour A, Shoemaker JK: Myogenic activity in autoregulation during low frequency oscillations. Auton Neurosci 2011;159:104-110.
- Tripathi KK: Very low frequency oscillations in the power spectra of heart rate variability during dry supine immersion and exposure to non-hypoxic hypobaria. Physiol Meas 2011;32:71-77.
- Aletti F, Chen X, Sala-Mercado JA, Hammond RL, O'Leary DS, Cerutti S, Baselli G, Mukkamala R: Identification of sources of low frequency variability of arterial blood pressure: cardiac output acts as a buffer and not as a source. Conf Proc IEEE Eng Med Biol Soc 2010;2010:3460-3462.
-
Lemmingson W: Uber das Vorkommen von Vasomotion im Retinalkreislauf. Graefe's Arch Clin Exp Ophthalmol 1968;1760:368.
- Bek T, Jeppesen P, Kanters J: Spontaneous high-frequency diameter oscillations of larger retinal arterioles are reduced in type 2 diabetes mellitus. Invest Ophthalmol Vis Sci 2012, E-pub ahead of print.
Article / Publication Details
First-Page Preview
Received: November 26, 2012
Accepted: March 20, 2013
Published online: July 27, 2013
Issue release date: August 2013
Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0
ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)
For additional information: https://www.karger.com/ORE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID