Ophthalmologica

Original Paper

Short- and Long-Term Phasing of Intraocular Pressure in Stable and Progressive Glaucoma

Fogagnolo P.a · Orzalesi N.a · Centofanti M.b, c · Oddone F.b · Manni G.c · Rossetti L.a

Author affiliations

aEye Clinic, Department of Medicine, Surgery and Odontology, Ospedale San Paolo, University of Milan, Milan, and bG.B. Bietti Foundation, IRCCS, and cEye Clinic, Tor Vergata University of Rome, Rome, Italy

Keywords: Intraocular pressureShort-term phasingLong-term phasingVisual fieldProgressive glaucoma

Related Articles for ""
Ophthalmologica 2013;230:87-92
https://doi.org/10.1159/000351647

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 2012
Accepted: March 26, 2013
Published online: June 21, 2013
Issue release date: August 2013

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: https://www.karger.com/OPH

Abstract

Aims: To evaluate short- (ST) and long-term (LT) intraocular pressure (IOP) in patients with stable (SG) and progressive glaucoma (PG). Materials and Methods: Fifty-two patients with treated glaucoma received a baseline 24-hour IOP curve and, every 6 months for 2 years, office-hour curve plus visual field test. Based on field changes, they were divided into 24 SG and 28 PG. ST and LT IOP mean, peak and fluctuation (standard deviation of measurements) were calculated. Parameters determining progression were evaluated by logistic regression. Results: At ST, SG and PG, respectively, had mean IOP of 16.8 ± 2.2 and 15.3 ± 1.8 mm Hg; peak of 19.7 ± 3.3, 17.4 ± 2.3 mm Hg; fluctuation of 2.3 ± 1.2, and 1.6 ± 0.6 mm Hg. LT parameters did not change in SG, whereas a significant increase of mean (+1.0 ± 1.5 mm Hg, p = 0.05), peak (2.0 ± 2.4 mm Hg, p = 0.0002), and fluctuation (0.5 ± 1.1 mm Hg, p = 0.008) occurred in PG. Mean, peak, and fluctuation were correlated, except mean and fluctuation in the long term. Association with progression was shown for change in mean IOP between ST and LT, and ST peak. Conclusions: SG and PG may show different IOP parameters when intensively measured at baseline and follow-up. Mean IOP change between ST and LT periods and ST peak were the parameters associated with progression.

© 2013 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 2012
Accepted: March 26, 2013
Published online: June 21, 2013
Issue release date: August 2013

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: https://www.karger.com/OPH

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2013, Vol.230, No. 2

August 2013

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Additional Information

Presented in part at the annual meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Fla., April - May 2008.

Contributorship Statement: All authors contributed to conception and design, acquisition of data, or analysis and interpretation of data; they all drafted the article and approved its final version.
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