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Tooth Movement

Editor(s): Kantarci A. (Cambridge, Mass.) 
Will L. (Boston, Mass.) 
Yen S. (Los Angeles, Calif.) 
Cover

Section 1: Biology and Metabolism of Alveolar Bone

Bone Remodeling Under Pathological Conditions

Xiao W.a, d · Li S.b, d · Pacios S.d, e · Wang Y.c, d · Graves D.T.d

Author affiliations

Departments of aPeriodontology and bImplantology, School and Hospital of Stomatology, Peking University, Beijing, and cDepartment of Dental Implantology, School and Hospital of Stomatology, Jilin University, Jilin, PR China; dDepartment of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa., USA; eDepartment of Periodontology, School of Dental Medicine, Universitat Internacional de Catalunya, Sant Cugat del Vallès, Spain

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Kantarci A, Will L, Yen S (eds): Tooth Movement. Front Oral Biol. Basel, Karger, 2016, vol 18, pp 17-27

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Article / Publication Details

First-Page Preview
Abstract of Section 1: Biology and Metabolism of Alveolar Bone

Published online: November 24, 2015
Cover Date: 2016

Number of Print Pages: 11
Number of Figures: 4
Number of Tables: 0

ISBN: 978-3-318-05479-8 (Print)
eISBN: 978-3-318-05480-4 (Online)

Abstract

Bone is masterfully programmed to repair itself through the coupling of bone formation following bone resorption, a process referred to as coupling. In inflammatory or other conditions, the balance between bone resorption and bone formation shifts so that a net bone loss results. This review focuses on four pathologic conditions in which remodeling leads to net loss of bone, postmenopausal osteoporosis, arthritis, periodontal disease, and disuse bone loss, which is similar to bone loss associated with microgravity. In most of these there is an acceleration of the resorptive process due to increased formation of bone metabolic units. This initially leads to a net bone loss since the time period of resorption is much faster than the time needed for bone formation that follows. In addition, each of these processes is characterized by an uncoupling that leads to net bone loss. Mechanisms responsible for increased rates of bone resorption, i.e. the formation of more bone metabolic units, involve enhanced expression of inflammatory cytokines and increased expression of RANKL. Moreover, the reasons for uncoupling are discussed which range from a decrease in expression of growth factors and bone morphogenetic proteins to increased expression of factors that inhibit Wnt signaling.

© 2016 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Section 1: Biology and Metabolism of Alveolar Bone

Published online: November 24, 2015
Cover Date: 2016

Number of Print Pages: 11
Number of Figures: 4
Number of Tables: 0

ISBN: 978-3-318-05479-8 (Print)
eISBN: 978-3-318-05480-4 (Online)


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