Annals of Nutrition and Metabolism
Original Paper
Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease: Do They Influence Patient-Related Outcomes?Rutten E.P.A.a · Calverley P.M.A.b · Casaburi R.c · Agusti A.d, e · Bakke P.f · Celli B.g, h · Coxson H.O.i · Crim C.j · Lomas D.A.k · MacNee W.l · Miller B.E.m · Rennard S.I.n · Scanlon P.D.o · Silverman E.K.g, h · Tal-Singer R.m · Vestbo J.p-r · Watkins M.L.j · Wouters E.F.M.s · on behalf of the ECLIPSE Investigators (Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints)aCenter of Expertise for Chronic Organ Failure (Ciro+), Horn, The Netherlands; bThe University of Liverpool, Liverpool, UK; cRehabilitation Clinical Trail Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, Calif., USA; dThe Thorax Institute, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, and eCIBER Enfermedades Respiratorias, Palma, Spain; fThe Institute of Medicine, University of Bergen, Bergen, Norway; gBrigham and Women's Hospital, and hHarvard Medical School, Boston, Mass., USA; iThe University of British Columbia, Vancouver, B.C., Canada; jGlaxoSmithKline, Research Triangle Park, Durham, N.C., USA; kCambridge Institute for Medical Research, University of Cambridge, Cambridge, and lThe University of Edinburgh, Edinburgh, UK; mGlaxoSmithKline, King of Prussia, Pa., nThe University of Nebreska Medical Center, Omaha, Nebr., and oMayo Clinic, Rochester, Minn., USA; pThe Respiratory Section, Hvidovre Hospital, Hvidovre, and qThe University of Copenhagen, Copenhagen, Denmark; rThe Manchester Academic Health Science Center, University of Manchester, Manchester, UK; sThe University of Maastricht, Maastricht, The Netherlands
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Article / Publication Details
Received: January 24, 2013
Accepted: May 22, 2013
Published online: November 07, 2013
Issue release date: December 2013
Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
Abstract
Aims: The follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality.
© 2013 S. Karger AG, Basel
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Article / Publication Details
Received: January 24, 2013
Accepted: May 22, 2013
Published online: November 07, 2013
Issue release date: December 2013
Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 4
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
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