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Original Paper

3-D Technology Used to Accurately Understand Equine Ileocolonic Aganglionosis

Muniz E.a · Lobo Ladd A.A.B.b · Lobo Ladd F.V.b · da Silva A.A.P.b · Kmit F.V.b · Borges A.S.e · Teixeira R.e · da Mota L.S.L.S.e · Belli C.B.c · de Zoppa A.L.V.d · da Silva L.C.L.C.d · de Melo M.P.f · Coppi A.A.b

Author affiliations

aLaboratory of Experimental Neurogastroenterology, Universidade Paranaense, Umuarama, bLaboratory of Stochastic Stereology and Chemical Anatomy, Department of Surgery, cDepartment of Internal Medicine, and dDepartment of Surgery, College of Veterinary Medicine and Animal Science, University of São Paulo, eDepartment of Veterinary Clinical Science, College of Veterinary Medicine and Animal Science, Universidade Estadual Paulista, Campus Botucatu, and fDepartment of Statistics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: May 21, 2013
Published online: July 25, 2013
Issue release date: October 2013

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Ileocolonic aganglionosis (ICA) is the congenital and hereditary absence of neurons that constitute the enteric nervous system and has been described in various species including humans - Hirschsprung's disease - and horses - overo lethal white syndrome (OLWS). Hirschsprung's disease affects circa 1 in 5,000 live births. At best, this disease means an inability to absorb nutrients from food (humans). At worse, in horses, it always means death. Despite our general understanding of the functional mechanisms underlying ICA, there is a paucity of reliable quantitative information about the structure of myenteric and submucosal neurons in healthy horses and there are no studies on horses with ICA. In light of these uncertainties, we have used design-based stereology to describe the 3-D structure - total number and true size - of myenteric and submucosal neurons in the ileum of ICA horses. Our study has shown that ICA affects all submucosal neurons and 99% of myenteric neurons. The remaining myenteric neurons (0.56%) atrophy immensely, i.e. 63.8%. We believe this study forms the basis for further research, assessing which subpopulation of myenteric neurons are affected by ileocolonic aganglionosis, and we would like to propose a new nomenclature to distinguish between a complete absence of neurons - aganglionosis - and a weaker form of the disease which we suggest naming ‘hypoganglionosis'. Our results are a step forward in understanding this disease structurally.

© 2013 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: May 21, 2013
Published online: July 25, 2013
Issue release date: October 2013

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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