Metabolic and Psychological Response to 7-Day Fasting in Obese Patients with and without Metabolic SyndromeLi C.a, b · Ostermann T.c · Hardt M.d · Lüdtke R.e · Broecker-Preuss M.f · Dobos G.d · Michalsen A.b, g
a Department of Traditional Chinese Medicine, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China b Institute of Social Medicine, Epidemiology, and Health Economics, Charité - Universitätsmedizin Berlin, c University of Witten/Herdecke, Center for Integrative Medicine, Herdecke, d Department of Complementary and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, e Karl and Veronica Carstens Foundation, Essen, f Department of Endocrinology and Division of Laboratory Research, University Hospital of Essen, University of Duisburg-Essen, g Department of Internal and Complementary Medicine, Immanuel Hospital Berlin, Germany
Andreas Michalsen, MD, PhD
Zentrum für Naturheilkunde, Immanuel Krankenhaus Berlin
Am kleinen Wannsee 5, 14106 Berlin, Germany
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Background: Extended modified fasting is a frequently practiced tradition in Europe. It is claimed to improve the cardiometabolic state and physical and psychological well-being by an evolutionary co-developed adaptation response. We aimed to investigate the cardiometabolic and psychological effects of a 7-day fast and differences of these responses between patients with or without metabolic syndrome (MetS). Methods: We investigated 30 female subjects (49.0 ± 8.1 years, BMI 30.4 ± 6.7 kg/m2) with (n = 12) and without (n = 18) MetS. All subjects participated in a 7-day fast according to Buchinger with a nutritional energy intake of 300 kcal/day and stepwise reintroduction of solid food thereafter. Outcomes were assessed baseline and after fasting and included measures of metabolic and glucoregulatory control, adipokines as well as psychological well-being as assessed by Profile of Mood States (POMS) and Hospital Anxiety and Depression Scale (HADS). Results: Mean weight decreased from 85.4 ± 18.8 kg to 79.7 ± 18.2 kg accompanied by systolic/diastolic blood pressure (BP) reduction of -16.2 mm Hg (95% CI: -9.1; -23.3 mm Hg) and -6.0 mm Hg (95% CI: -1.8; -10.3 mm Hg), each p < 0.001 and p = 0.005. Fasting led to marked decreases of levels of LDL-cholesterol, leptin, and insulin and increases of levels of adiponectin, leptin receptors, and resistin. Fasting-induced mood enhancement was reflected by decreased anxiety, depression, fatigue, and improved vigor. Patients with MetS showed some greater changes in B P, LDL-cholesterol, triglycerides, adiponectin, leptin, and sleep quality. Fasting was well-tolerated. Conclusions: Our results point to marked beneficial responses to 7-day modified fasting and a potential role in the prevention of the MetS. Randomized trials with longer observation periods should test the clinical effectiveness of fasting in metabolic diseases.
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