European Neurology
Original Paper
Smoking Status and Severity of Ischemic Stroke. A Population-Based StudyBéjot Y. · Jacquin A. · Daubail B. · Lainay C. · Janoura S. · Aboa-Eboulé C. · Durier J. · Giroud M.Dijon Stroke Registry, EA4184, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, Dijon, France
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: May 24, 2013
Accepted: August 12, 2013
Published online: December 05, 2013
Issue release date: February 2014
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Abstract
We aimed to investigate the impact of smoking status on clinical severity in patients with ischemic stroke event (IS). Patients were prospectively identified among residents of the city of Dijon, France (ca. 151,000 inhabitants), using a population-based registry, between 2006 and 2011. Demographic and clinical data were recorded. The initial clinical severity was quantified by the means of the National Institutes of Health Stroke Scale (NIHSS). Multivariable ordinal logistic regression was used to assess the effect of smoking status on severity. Among the 1,056 recorded patients with IS, data about smoking status were available for 973 (92.1%), of whom 658 (67.3%) were non-smokers, 187 (19.2%) were current smokers, and 128 (13.2%) were former smokers. Compared with non-smoking, former smoking was associated with less severe IS (OR 0.55; 95% CI 0.38-0.82, p = 0.003), whereas this association was not found for current smokers (OR 0.97; 95% CI 0.69-1.36, p = 0.856). Further work is needed to understand the underlying mechanisms of this finding.
© 2013 S. Karger AG, Basel
Related Articles:
References
- Shinton R, Beevers G: Meta-analysis of relation between cigarette smoking and stroke. BMJ 1989;298:789-794.
- Purcell IF, Newall N, Farrer M: Lower cardiac mortality in smokers following thrombolysis for acute myocardial infarction may be related to more effective fibrinolysis. QJM 1999;92:327-333.
- Ruiz-Bailen M, de Hoyos EA, Reina-Toral A, Torres-Ruiz JM, Alvarez-Bueno M, Gomez Jimenez FJ: Paradoxical effect of smoking in the Spanish population with acute myocardial infarction or unstable angina: results of the ARIAM Register. Chest 2004;125:831-840.
- Bang OY, Park HY, Lee PH, Kim GM, Chung CS, Lee KH: Improved outcome after atherosclerotic stroke in male smoker. J Neurol Sci 2007;260:43-48.
- Ovbiagele B, Saver JL: The smoking-thrombolysis paradox and acute ischemic stroke. Neurology 2005;65:293-295.
- Weng WC, Huang WY, Chien YY, Wu CL, Su FC, Hsu HJ, Lee TH, Peng TI: The impact of smoking on the severity of acute ischemic stroke. J Neurol Sci 2011;308:94-97.
- Kimura K, Minematsu K, Yamaguchi T, Japan Multicenter Stroke Investigators' Collaboration (J-MUSIC): Atrial fibrillation as a predictive factor for severe stroke and early death in 15,831 patients with acute ischaemic stroke. J Neurol Neurosurg Psychiatry 2005;76:679-683.
- Appelros P, Nydevik I, Seiger A, Terént A: Predictors of severe stroke: influence of preexisting dementia and cardiac disorders. Stroke 2002;33:2357-2362.
- Lyrer PA, Fluri F, Gostynski M, Bonati L, Papa S, Ajdacic-Gross V, Engelter ST: Stroke severity, its correlates and impact on thrombolysis in a population-based study. Eur Neurol 2009;62:231-236.
- Ovbiagele B, Weir CJ, Saver JL, Muir KW, Lees KR, IMAGES Investigators: Effect of smoking status on outcome after acute ischemic stroke. Cerebrovasc Dis 2006;21:260-265.
- Krarup LH, Truelsen T, Gluud C, Andersen G, Zeng X, Kõrv J, Oskedra A, Boysen G, ExStroke Pilot Trial Group: Prestroke physical activity is associated with severity and long-term outcome from first-ever stroke. Neurology 2008;71:1313-1318.
- Malmgren R, Warlow C, Bamford J, Sandercock P: Geographical and secular trends in stroke incidence. Lancet 1987;2:1196-1200.
- Sudlow CL, Warlow CP: Comparing stroke incidence worldwide: what makes studies comparable? Stroke 1996;27:550-558.
- Béjot Y, Rouaud O, Jacquin A, Osseby GV, Durier J, Manckoundia P, Pfitzenmeyer P, Moreau T, Giroud M: Stroke in the very old: incidence, risk factors, clinical features, outcomes and access to resources - a 22-year population-based study. Cerebrovasc Dis 2010;29:111-121.
-
WHO: The World Health Report 2000: Health Systems Improving Performance. Geneva, WHO, 2000.
- Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE 3rd: Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35-41.
- Ruiz-Bailén M, de Hoyos EA, Reina-Toral A, Torres-Ruiz JM, Alvarez-Bueno M, Gómez Jiménez FJ, ARIAM Group: Paradoxical effect of smoking in the Spanish population with acute myocardial infarction or unstable angina: results of the ARIAM Register. Chest 2004;125:831-840.
- Williams LS, Yilmaz EY, Lopez-Yunez AM: Retrospective assessment of initial stroke severity with the NIH Stroke Scale. Stroke 2000;31:858-862.
- De Raedt S, Haentjens P, De Smedt A, Brouns R, Uyttenboogaart M, Luijckx GJ, De Keyser J: Pre-stroke use of β-blockers does not affect ischaemic stroke severity and outcome. Eur J Neurol 2012;19:234-240.
- Bath PM, Lees KR, Schellinger PD, Altman H, Bland M, Hogg C, Howard G, Saver JL, European Stroke Organisation Outcomes Working Group: Statistical analysis of the primary outcome in acute stroke trials. Stroke 2012;43:1171-1178.
- Fischer U, Baumgartner A, Arnold M, Nedeltchev K, Gralla J, De Marchis GM, Kappeler L, Mono ML, Brekenfeld C, Schroth G, Mattle HP: What is a minor stroke? Stroke 2010;41:661-666.
- Fujita M, Nakae I, Kihara Y, Hasegawa K, Nohara R, Ueda K, Tamaki S, Otsuka K, Sasayama S: Determinants of collateral development in patients with acute myocardial infarction. Clin Cardiol 1999;22:595-599.
- Nakamura K, Nakagawa H, Sakurai M, Murakami Y, Irie F, Fujiyoshi A, Okamura T, Miura K, Ueshima H, EPOCH-JAPAN Research Group: Influence of smoking combined with another risk factor on the risk of mortality from coronary heart disease and stroke: pooled analysis of 10 Japanese cohort studies. Cerebrovasc Dis 2012;33:480-491.
- Lu M, Ye W, Adami HO, Weiderpass E: Stroke incidence in women under 60 years of age related to alcohol intake and smoking habit. Cerebrovasc Dis 2008;25:517-525.
Article / Publication Details
Received: May 24, 2013
Accepted: August 12, 2013
Published online: December 05, 2013
Issue release date: February 2014
Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 2
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
