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Original Paper

Aquagenic Wrinkling of the Palms and Cystic Fibrosis: An Italian Study with Controls and Genotype-Phenotype Correlations

Chinazzo C.a · De Alessandri A.b · Menoni S.c · Romanisio G.b · Rebora A.a · Rongioletti F.a

Author affiliations

aSection of Dermatology, DISSAL, bCF Center, G. Gaslini Institute, and cBiostatistic Unit, University of Genoa, Genoa, Italy

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Dermatology 2014;228:60-65

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 30, 2013
Accepted: August 15, 2013
Published online: January 09, 2014
Issue release date: February 2014

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Aims: The primary aim was to determine the prevalence of aquagenic wrinkling of the palms (AWP) in patients with cystic fibrosis (CF) compared to controls, and secondarily to evaluate genotype-phenotype correlations among CF subjects found to have AWP. Methods: Fifty-eight patients with CF underwent a hand immersion test in tap water. Twenty-three of their CF carrier relatives and 7 subjects with a negative genetic test for CF were recruited as controls. Secondary analyses explored associations with genotype, pulmonary function, and sweat electrolyte levels in all subjects with and without AWP. Additional information about atopic diathesis, hyperhidrosis of the palms and drug intake were also collected. Results: Thirty-one of the patients with CF (53.4%) exhibited AWP, in contrast to only 2 carriers (8.7%) and none in the control group. No correlation was found between CF genotype and AWP score severity. Twenty-three (39.7%) CF patients reported a history of hyperhidrosis, and in 17 of them (74%) AWP had been provoked. No correlation with history of atopy and lung function was noted. The difference between CF patients with hyperhidrosis and those without was highly significant (p = 0.016). Salt concentrations were significantly higher in patients with AWP. Conclusions: AWP is linked to CF and its diagnosis should lead the patients to a genetic or sweat test for CF. We found a significant association with hyperhidrosis and sweat electrolytes which supports the ‘hyperconcentrated sweat' pathogenetic theory of AWP.

© 2014 S. Karger AG, Basel


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    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: April 30, 2013
Accepted: August 15, 2013
Published online: January 09, 2014
Issue release date: February 2014

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 4

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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