At the Cutting Edge
Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health DisordersNousen E.K.a · Franco J.G.a · Sullivan E.L.a, b
aDivision of Diabetes, Obesity, and Metabolism, Oregon National Primate Research Center, Beaverton, Oreg., and bDepartment of Biology, University of Portland, Portland, Oreg., USA
Elinor L. Sullivan
University of Portland
5000 N. Willamette Blvd.
Portland, OR 97203 (USA)
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The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed.
© 2013 S. Karger AG, Basel
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