Ophthalmologica
Original Paper
Dexamethasone Intravitreal Implant for Treatment of Patients with Persistent Diabetic Macular EdemaDutra Medeiros M.a · Postorino M.a · Navarro R.a · Garcia-Arumí J.a, b · Mateo C.a · Corcóstegui B.aaInstituto de Microcirugia Ocular and bHospital Universitario Vall d'Hebron, Barcelona, Spain
Keywords: DiabetesRefractory macular edemaOzurdex |
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Article / Publication Details
Received: July 02, 2013
Accepted: September 13, 2013
Published online: December 19, 2013
Issue release date: March 2014
Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
Abstract
Purpose: To report the 6-month anatomical and best-corrected visual acuity (BCVA) response after primary intravitreal dexamethasone implantation (Ozurdex®) in patients with refractory diabetic macular edema (DME). Methods: Retrospective review of the medical records of 58 patients with decreased visual acuity, due to refractory DME, who underwent a single injection of Ozurdex between November 2010 and January 2012, at the Instituto de Microcirurgia Ocular, Barcelona, Spain. Results: At baseline, the mean foveal thickness (FT) was 543.24 ± 156.51 μm. Mean (±SD) values of FT did decrease to 346.82 ± 123.74 μm at month 1 and 341.12 ± 129.64 μm at month 3. Data on the 6-month follow-up showed a mild increase to 420.16 ± 152.15 μm. All of the FT reduction outcomes were statistically significant, with respect to baseline data (p = 0.0001). The baseline BCVA data was 0.66 ± 0.36 logarithm of the minimum angle of resolution (logMAR). The mean BCVA improved to 0.52 ± 0.32 logMAR (p = 0.0001) and 0.44 ± 0.27 logMAR (p = 0.0001) after 1 and 3 months, respectively. At the last visit (6-month follow-up), the mean BCVA increased to 0.51 ± 0.31 logMAR (p = 0.0001). Conclusions: In this study, intravitreal treatment with a dexamethasone implant safely reduced DME and improved visual acuity in a difficult-to-treat patient population with long-standing refractory DME.
© 2013 S. Karger AG, Basel
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Article / Publication Details
Received: July 02, 2013
Accepted: September 13, 2013
Published online: December 19, 2013
Issue release date: March 2014
Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 2
ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)
For additional information: https://www.karger.com/OPH
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