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Novel Insights from Clinical Practice

Gonadotropin-Dependent Precocious Puberty in an 8-Year-Old Boy with Leydig Cell Testicular Tumor

Santos-Silva R.a · Bonito-Vítor A.a · Campos M.b · Fontoura M.c

Author affiliations

Departments of aPediatrics, and bPediatric Surgery, Hospital S. João, Porto, and cDivision of Pediatric Endocrinology, Department of Pediatrics, Hospital S. João, Oporto Medical School, Porto, Portugal

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Horm Res Paediatr 2014;82:133-137

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: July 30, 2013
Accepted: December 17, 2013
Published online: May 24, 2014
Issue release date: August 2014

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP

Abstract

Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose hormonal investigation showed luteinizing hormone-independent testosterone hypersecretion. Although no palpable mass was present, scrotal ultrasound revealed a testicular tumor. Testis-sparing tumor resection was performed and the histopathology analysis showed a Leydig cell tumor. After surgery the testosterone levels remained high and further examination showed gonadotropin-dependent precocious puberty, which is believed to be likely caused by the activation of the hypothalamic-pituitary axis due to a long-term exposition to sex steroids. He is currently being treated with a long-acting gonadotropin-releasing hormone analog and the process of sexual precocity has until now been suppressed.

© 2014 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: July 30, 2013
Accepted: December 17, 2013
Published online: May 24, 2014
Issue release date: August 2014

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 1

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: https://www.karger.com/HRP


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