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Gonadotropin-Dependent Precocious Puberty in an 8-Year-Old Boy with Leydig Cell Testicular TumorSantos-Silva R.a · Bonito-Vítor A.a · Campos M.b · Fontoura M.c
Departments of aPediatrics, and bPediatric Surgery, Hospital S. João, Porto, and cDivision of Pediatric Endocrinology, Department of Pediatrics, Hospital S. João, Oporto Medical School, Porto, Portugal
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Article / Publication Details
Leydig cell testicular tumors are very rare in children. They can present as gonadotropin-independent precocious puberty due to excess androgen secretion. We report the case of an 8-year-old boy with isosexual precocity whose hormonal investigation showed luteinizing hormone-independent testosterone hypersecretion. Although no palpable mass was present, scrotal ultrasound revealed a testicular tumor. Testis-sparing tumor resection was performed and the histopathology analysis showed a Leydig cell tumor. After surgery the testosterone levels remained high and further examination showed gonadotropin-dependent precocious puberty, which is believed to be likely caused by the activation of the hypothalamic-pituitary axis due to a long-term exposition to sex steroids. He is currently being treated with a long-acting gonadotropin-releasing hormone analog and the process of sexual precocity has until now been suppressed.
© 2014 S. Karger AG, Basel
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