Aging

Facts and Theories

Editor(s): Robert, L. (Paris)
Fulop, T. (Sherbrooke, QC)
 

On the Immunological Theory of Aging

Fulop T.a, b · Witkowski J.M.d · Pawelec G.e · Alan C.a, c · Larbi A.f

Author affiliations

aResearch Center on Aging, bGeriatrics Division, Department of Medicine, and cDepartment of Family Medicine, University of Sherbrooke, Sherbrooke, Que., Canada; dDepartment of Pathophysiology, Medical University of Gdansk, Gdansk, Poland; eCenter for Medical Research, University of Tübingen, Tübingen, Germany; fSingapore Immunology Network (SIgN), Biopolis, Agency for Science Technology and Research (A*STAR), Singapore, Singapore

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Robert L, Fulop T (eds): Aging: Facts and Theories. Interdiscipl Top Gerontol. Basel, Karger, 2014, vol 39, pp 163-176
https://doi.org/10.1159/000358904

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Article / Publication Details

First-Page Preview
Abstract of  

Published online: May 13, 2014
Cover Date: 2014

Number of Print Pages: 14
Number of Figures: 3
Number of Tables: 0

ISBN: 978-3-318-02652-8 (Print)
eISBN: 978-3-318-02653-5 (Online)

Abstract

Aging is a complex phenomenon the cause of which is not fully understood, despite the plethora of theories proposed to explain it. As we age, changes in essentially all physiological functions, including immunity, are apparent. Immune responses decrease with aging, contributing to the increased incidence of different chronic diseases with an inflammatory component (sometimes referred to as ‘inflamm-aging'). It is clear from many studies that human longevity may be influenced by these changes in the immune system, but how they proceed is not clearly determined. In this chapter, we will review the age-related changes in the immune response and assess the validity of the immune theory of aging (i.e. that these changes in immune response are the primary cause of aging). Many data in humans support the notion that age-associated immune dysfunction may at least in part explain the aging process. Explanatory power may be enhanced by combination with other theories such as the free radical theory. More longitudinal studies are needed to corroborate the immune theory of aging.

© 2014 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of  

Published online: May 13, 2014
Cover Date: 2014

Number of Print Pages: 14
Number of Figures: 3
Number of Tables: 0

ISBN: 978-3-318-02652-8 (Print)
eISBN: 978-3-318-02653-5 (Online)

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