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Original Paper

Complicated and Uncomplicated Peptic Ulcer Disease: Altered Symptom Response to a Nutrient Challenge Linked to Gastric Motor Dysfunction

Gururatsakul M.a, b · Holloway R.H.a, b · Bellon M.c · Bartholomeusz D.b, c · Talley N.J.d · Holtmann G.J.b, e

Author affiliations

aDepartment of Gastroenterology and Hepatology, Royal Adelaide Hospital, bDiscipline of Medicine, University of Adelaide, and cDepartment of Nuclear Medicine, PET, and Bone Densitometry, Royal Adelaide Hospital, Adelaide, S.A., dFaculty of Health, University of Newcastle, Newcastle, N.S.W., and eDepartment of Gastroenterology and Hepatology, Princess Alexandra Hospital, Woolloongabba, Qld., Australia

Related Articles for ""

Digestion 2014;89:239-246

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 17, 2013
Accepted: February 16, 2014
Published online: June 04, 2014
Issue release date: June 2014

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background: Bleeding peptic ulcer (BPU) frequently occurs in the absence of preceding dyspeptic symptoms. We have observed that patients with BPU had a diminished symptom response to nutrient challenge test compared to uncomplicated peptic ulcer disease (uPUD). We postulated that more symptoms are manifest in patients with uPUD than BPU because there are greater derangements in gastric motor function. Aim: To assess gastric emptying in patients with BPU, uPUD and healthy controls (HC). Methods: We studied 17 patients with BPU, 10 with uPUD, and 15 HC. After an 8-hour fast, subjects ingested 200 ml of an enteral feeding solution, containing 5 MBq 99mTc-rhenium sulphide colloid, every 5 min up to a cumulative volume of 800 ml. Gastric emptying was measured by scintigraphy for the total, proximal and distal stomach. Results: Patients with uPUD had significantly higher gastric retention in the proximal and total stomach at 100 min than HC and BPU, while BPU had similar percent retention to HC. Patients with uPUD had significantly higher cumulative symptom response to the nutrient challenge than did HC and BPU, while BPU had similar symptom responses to HC. Conclusions: Patients with uPUD have significantly delayed gastric emptying compared to HC and BPU. Data suggest that in addition to alterations of visceral sensory function, altered gastric motor function occurs during a nutrient challenge in uPUD but not BPU. Gastric motor function may contribute to the manifestation of dyspeptic symptoms in PUD.

© 2014 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 17, 2013
Accepted: February 16, 2014
Published online: June 04, 2014
Issue release date: June 2014

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 2

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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