International Archives of Allergy and Immunology
Review
Clinical Studies in Oral Allergen-Specific Immunotherapy: Differences among AllergensSato S.a · Yanagida N.b · Ogura K.a · Imai T.a, c · Utsunomiya T.a, d · Iikura K.b · Goto M.a, e · Asaumi T.b · Okada Y.b · Koike Y.b · Syukuya A.b · Ebisawa M.aaClinical Research Center for Allergy and Rheumatology, and bDepartment of Pediatrics, Sagamihara National Hospital, Sagamihara, cDepartment of Pediatrics, Showa University, Tokyo, dDepartment of Pediatrics, Takasaki National Hospital, Gunma, and eDepartment of Pediatrics, Beppu National Hospital, Oita, Japan
|
|
Int Arch Allergy Immunol 2014;164:1-9
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
* The final prices may differ from the prices shown due to specifics of VAT rules.
Article / Publication Details
First-Page Preview
Published online: April 29, 2014
Issue release date: June 2014
Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3
ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)
For additional information: https://www.karger.com/IAA
Abstract
Oral immunotherapy (OIT) is a significant focus of treatment of food allergy. OIT appears to be effective in inducing desensitization, however, patients receiving OIT frequently developmild/moderate symptoms during the therapy. It has not been clearly established whether the clinical tolerance induced by OIT resembles natural tolerance. According to our data, the efficacy of OIT is different among food antigens, and it is comparatively difficult to achieve the clinical tolerance in milk OIT. Moreover, the definitive evidence of efficacy and safety with long-term therapy is limited. Further studies need to be offered to patients in clinical practice. Recently, novel treatments for food allergy, sublingual and epicutaneous immunotherapy, and combination treatment with an anti-IgE monoclonal antibody (omalizumab), have been examined in some studies. OIT combined with omalizumab increased the threshold doses of food without adverse reactions and may be of benefit in food allergy treatment. More studies are needed to demonstrate long-term safety and treatment benefits in a larger patient cohort.
© 2014 S. Karger AG, Basel
Related Articles:
References
- Sampson HA: Food allergy. Part 2: diagnosis and management. J Allergy Clin Immunol 1999;103:981-989.
- Sicherer SH, Furlong TJ, Munoz-Furlong A, Burks AW, Sampson HA: A voluntary registry for peanut and tree nut allergy: characteristics of the first 5149 registrants. J Allergy Clin Immunol 2001;108:128-132.
- Cohen BL, Noone S, Munoz-Furlong A, Sicherer SH: Development of a questionnaire to measure quality of life in families with a child with food allergy. J Allergy Clin Immunol 2004;114:1159-1163.
- Permaul P, Stutius LM, Sheehan WJ, Rangsithienchai P, Walter JE, Twarog FJ, et al: Sesame allergy: role of specific IgE and skin prick testing in predicting food challenge results. J Allergy Clin Immunol 2009;123:S24.
- Zavalkoff S, Kagan R, Joseph L, St-Pierre Y, Clarke A: The value of sesame-specific IgE levels in predicting sesame allergy. J Allergy Clin Immunol 2008;121:1508-1510.
- Skripak JM, Nash SD, Rowley H, Brereton NH, Oh S, Hamilton RG, et al: A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2008;122:1154-1160.
- Buchanan AD, Green TD, Jones SM, Scurlock AM, Christie L, Althage KA, et al: Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 2007;119:199-205.
- Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, et al: Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009;124:292.e97-300.e97.
- Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG: A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 2004;59:980-987.
- Blumchen K, Ulbricht H, Staden U, Dobberstein K, Beschorner J, de Oliveira LC, et al: Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol 2010;126:83.e1-91.e1.
- Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, Schroeder JT, Hamilton RG, Boden S, et al: The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol 2012;129:448.e5-455.e5.
- Longo G, Barbi E, Berti I, Meneghetti R, Pittalis A, Ronfani L, et al: Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008;121:343-347.
- Staden U, Blumchen K, Blankenstein N, Dannenberg N, Ulbricht H, Dobberstein K, et al: Rush oral immunotherapy in children with persistent cow's milk allergy. J Allergy Clin Immunol 2008;122:418-419.
- Yu GP, Weldon B, Neale-May S, Nadeau KC: The safety of peanut oral immunotherapy in peanut-allergic subjects in a single-center trial. Int Arch Allergy Immunol 2012;159:179-182.
- Burks AW, Jones SM, Wood RA, Fleischer DM, Sicherer SH, Lindblad RW, et al: Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 2012;367:233-243.
- Pajno GB, Caminiti L, Ruggeri P, De Luca R, Vita D, La Rosa M, et al: Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study. Ann Allergy Asthma Immunol 2010;105:376-381.
- Varshney P, Jones SM, Scurlock AM, Perry TT, Kemper A, Steele P, et al: A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol 2011;127:654-660.
-
Ebisawa M, Sato S, Utsunomiya T, Hayashi N, Imai T, Yanagida T: Rush oral immunotherapy for the treatment of hen's egg- and cow's milk-induced anaphylaxis; in Marone G, Triggiani M, Genovese A (eds): Translational Science: From Basic to Clinical Immunology and Allergy. Pisa, Pacini, 2012, pp 359-364.
- Hofmann AM, Scurlock AM, Jones SM, Palmer KP, Lokhnygina Y, Steele PH, et al: Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol 2009;124:286.e6-291.e6.
- Varshney P, Steele PH, Vickery BP, Bird JA, Thyagarajan A, Scurlock AM, et al: Adverse reactions during peanut oral immunotherapy home dosing. J Allergy Clin Immunol 2009;124:1351-1352.
- Sanchez-Garcia S, Rodriguez Del Rio P, Escudero C, Martinez-Gomez MJ, Ibanez MD: Possible eosinophilic esophagitis induced by milk oral immunotherapy. J Allergy Clin Immunol 2012;129:1155-1157.
- Brozek JL, Terracciano L, Hsu J, Kreis J, Compalati E, Santesso N, et al: Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis. Clin Exp Allergy 2011;42:363-374.
- Staden U, Rolinck-Werninghaus C, Brewe F, Wahn U, Niggemann B, Beyer K: Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007;62:1261-1269.
- Harada S, Horikawa T, Ashida M, Kamo T, Nishioka E, Ichihashi M: Aspirin enhances the induction of type I allergic symptoms when combined with food and exercise in patients with food-dependent exercise-induced anaphylaxis. Br J Dermatol 2001;145:336-339.
- Patriarca G, Nucera E, Pollastrini E, Roncallo C, De Pasquale T, Lombardo C, et al: Oral specific desensitization in food-allergic children. Dig Dis Sci 2007;52:1662-1672.
- Rolinck-Werninghaus C, Staden U, Mehl A, Hamelmann E, Beyer K, Niggemann B: Specific oral tolerance induction with food in children: transient or persistent effect on food allergy? Allergy 2005;60:1320-1322.
- Scurlock AM, Vickery BP, Hourihane JO, Burks AW: Pediatric food allergy and mucosal tolerance. Mucosal Immunol 2010;3:345-354.
- Akdis M, Akdis CA: Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2007;119:780-791.
- Akdis CA: Therapies for allergic inflammation: refining strategies to induce tolerance. Nat Med 2012;18:736-749.
- Vickery BP, Pons L, Kulis M, Steele P, Jones SM, Burks AW: Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance. Ann Allergy Asthma Immunol 2010;105:444-450.
- Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG: Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol 2009;123:789.e20-794.e20.
- Enrique E, Pineda F, Malek T, Bartra J, Basagana M, Tella R, et al: Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J Allergy Clin Immunol 2005;116:1073-1079.
- Fleischer DM, Burks AW, Vickery BP, Scurlock AM, Wood RA, Jones SM, et al: Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial. J Allergy Clin Immunol 2013;131:119.e7-127.e7.
- Chin SJ, Vickery BP, Kulis MD, Kim EH, Varshney P, Steele P, et al: Sublingual versus oral immunotherapy for peanut-allergic children: a retrospective comparison. J Allergy Clin Immunol 2013;132:476.e2-478.e2.
- Lieberman JA, Chehade M: Use of omalizumab in the treatment of food allergy and anaphylaxis. Curr Allergy Asthma Rep 2013;13:78-84.
- Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT: Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy. Immunol Allergy Clin North Am 2012;32:111-133.
- Dupont C, Kalach N, Soulaines P, Legoue-Morillon S, Piloquet H, Benhamou PH: Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. J Allergy Clin Immunol 2010;125:1165-1167.
Article / Publication Details
First-Page Preview
Published online: April 29, 2014
Issue release date: June 2014
Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3
ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)
For additional information: https://www.karger.com/IAA
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
