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Aging and Health - A Systems Biology Perspective

Editor(s): Yashin A.I. (Durham, N.C.) 
Jazwinski S.M. (New Orleans, La.) 
Cover

Introduction to the Theory of Aging Networks

Witten T.M.

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Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Va., USA

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Yashin AI, Jazwinski SM (eds): Aging and Health - A Systems Biology Perspective. Interdiscipl Top Gerontol. Basel, Karger, 2015, vol 40, pp 1-17

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Article / Publication Details

First-Page Preview
Abstract of  

Published online: October 14, 2014
Cover Date: 2015

Number of Print Pages: 17
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-318-02729-7 (Print)
eISBN: 978-3-318-02730-3 (Online)

Abstract

This chapter will briefly address the history of systems biology and complexity theory and its use in understanding the dynamics of aging at the ‘omic' level of biological organization. Using the idea of treating a biological organism like a network, we will examine how network mathematics, particularly graph theory, can provide deeper insight and can even predict potential genes and proteins that are related to the control of organismal life span. We will begin with a review of the history of network analysis at the cellular level and follow that by an introduction to the various commonly used network analysis variables. We will then demonstrate how these variables can be used to predict potential targets for experimental analysis. Lastly, we will close with some of the challenges that network methods face.

© 2015 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of  

Published online: October 14, 2014
Cover Date: 2015

Number of Print Pages: 17
Number of Figures: 1
Number of Tables: 0

ISBN: 978-3-318-02729-7 (Print)
eISBN: 978-3-318-02730-3 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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