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Aging and Health - A Systems Biology Perspective

Editor(s): Yashin A.I. (Durham, N.C.) 
Jazwinski S.M. (New Orleans, La.) 
Cover

Modulating mTOR in Aging and Health

Johnson S.C. · Sangesland M. · Kaeberlein M. · Rabinovitch P.S.

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Department of Pathology, University of Washington, Seattle, Wash., USA

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Yashin AI, Jazwinski SM (eds): Aging and Health - A Systems Biology Perspective. Interdiscipl Top Gerontol. Basel, Karger, 2015, vol 40, pp 107-127

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Article / Publication Details

First-Page Preview
Abstract of  

Published online: October 13, 2014
Cover Date: 2015

Number of Print Pages: 21
Number of Figures: 2
Number of Tables: 1

ISBN: 978-3-318-02729-7 (Print)
eISBN: 978-3-318-02730-3 (Online)

Abstract

The physiological responses to nutrient availability play a central role in aging and disease. Genetic and pharmacological studies have identified highly conserved cellular signaling pathways that influence aging by regulating the interface between nutrient and hormone cues and cellular growth and maintenance. Among these pathways, the mechanistic target of rapamycin (mTOR) has been most reproducibly shown to modulate aging in evolutionarily diverse organisms as reduction in mTOR activity extends life span from yeast to rodents. mTOR has been shown to play a role in a broad range of diseases, and is of particular interest to human health and aging due to the availability of clinically approved pharmacological agents targeting the mTOR complexes and other components of the mTOR signaling network. Characterizing the role of mTOR in aging and health promises to provide new avenues for intervention in human aging and disease through modulation of this signaling pathway.

© 2015 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of  

Published online: October 13, 2014
Cover Date: 2015

Number of Print Pages: 21
Number of Figures: 2
Number of Tables: 1

ISBN: 978-3-318-02729-7 (Print)
eISBN: 978-3-318-02730-3 (Online)


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