Affects, Interoception and Psychopathology
Binding Action and Emotion in First-Episode SchizophreniaFerri F.a-d · Costantini M.a,c,d · Salone A.c, d · Ebisch S.c, d · De Berardis D.e, f · Mazzola V.h · Arciero G.g, i · Ferro F.M.e · Di Giannantonio M.c-e · Romani G.L.c, d · Gallese V.b
aMind, Brain Imaging and Neuroethics, University of Ottawa Institute of Mental Health Research, Ottawa, Ont., Canada; bDepartment of Neuroscience, University of Parma, Parma, cDepartment of Neuroscience, Imaging and Clinical Sciences and dInstitute for Advanced Biomedical Technologies, University G. d'Annunzio, and eInstitute of Psychiatry, G. d'Annunzio University Chieti-Pescara, Chieti, fPsychiatric Service of Diagnosis and Treatment, Department of Mental Health, Hospital G. Mazzini, National Health Service, Teramo, and gInstitute of Post-Rationalist Psychology, Rome, Italy; hSwiss Center for Affective Sciences, University of Geneva, and iDepartment of Mental Health and Psychiatry, University Hospital of Geneva, Geneva, Switzerland
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Background/Aims: Several components of social cognition are compromised in schizophrenia (SCZ) from the early stage of the illness. In this study we first investigated whether mirror neuron-driven embodied simulation (mnES) is altered in first-episode SCZ. Second, we tested whether emotional cues impact on the mnES in SCZ patients. Methods: Twenty-two SCZ patients and 22 healthy controls (HCs) observed goal-related actions in either a neutral or emotional context during functional magnetic resonance imaging scanning. Results: Observation of neutral action elicited a lower activity in the frontoparietal network in SCZ patients, as compared to HCs. Particularly, activation in the left inferior parietal lobule in response to the same condition negatively correlated with patients' self-experience disturbances. Moreover, observation of an action performed by an angry agent produced poorer neural activity in the right anterior insula in SCZ patients as compared to HCs. This difference was mostly due to the negative β-values shown by SCZ patients, which positively correlated with their empathy scores. No differences were found contingent upon the observation of an action performed by a happy agent. Conclusion: Our results show that emotional cues allow SCZ patients to partially recover mnES. However, their understanding of the emotional components of the actions of others will likely remain deficient.
© 2014 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.