Neurodegenerative Diseases

Original Paper

Frontal Corpus Callosum Alterations in Progressive Supranuclear Palsy but Not in Parkinson's Disease

Rosskopf J.a · Müller H.-P.a · Huppertz H.-J.b · Ludolph A.C.a · Pinkhardt E.H.a · Kassubek J.a

Author affiliations

aDepartment of Neurology, University of Ulm, Ulm, Germany; bSwiss Epilepsy Centre, Zurich, Switzerland

Keywords: Diffusion tensor imagingFractional anisotropyMagnetic resonance imagingParkinsonian syndromes

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Neurodegener Dis 2014;14:184-193
https://doi.org/10.1159/000367693

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 25, 2014
Accepted: August 19, 2014
Published online: November 01, 2014
Issue release date: January 2015

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD

Abstract

Background: Frontal lobe involvement is considered a clinical and magnetic resonance imaging (MRI) feature in later stages of progressive supranuclear palsy (PSP). Objective: Diffusion tensor imaging (DTI) was used to investigate the integrity of frontal pathways in PSP and Parkinson's disease (PD) patients. Methods: DTI and 3-D MRI were performed in 15 PSP patients (parkinsonism subtype: n = 8; Richardson subtype: n = 7), 15 PD patients, and 18 matched controls. DTI analysis was performed in order to identify differences along frontal white matter structures including the corpus callosum (CC) and was complemented by atlas-based volumetry and planimetry. Results: Significantly reduced regional fractional anisotropy was observed for PSP patients versus controls and PSP versus PD patients, respectively, in frontal areas including the area II of the CC and bilaterally in the callosal radiation. The DTI findings correlated with frontal lobe volumes. These differences were not observed between PD patients and controls. Conclusion: DTI identified a PSP-associated microstructural alteration pattern in the frontal lobes and in the CC area II including the corresponding bilateral callosal radiation tracts that could not be identified in both control samples, supporting the prominent PSP-associated frontal involvement as a potential neuroimaging marker.

© 2014 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 25, 2014
Accepted: August 19, 2014
Published online: November 01, 2014
Issue release date: January 2015

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 4

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: https://www.karger.com/NDD

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2014, Vol.14, No. 4

January 2015

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J.R. and H.-P.M. contributed equally to this work.
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