Metabolic Syndrome and Obesity in Childhood and AdolescenceEditor(s): Kiess W. (Leipzig)
Wabitsch M. (Ulm)
Maffeis C. (Verona)
Sharma A.M. (Edmonton, Alta.)
Societal Aspects and Prevention
Metabolic Syndrome and the ‘Western Diet': Science and PoliticsLustig R.H.a, b
aDivision of Pediatric Endocrinology, Department of Pediatrics, UCSF Benioff Children's Hospital and the bPhilip R. Lee Institute for Health Policy Studies, University of California, San Francisco, Calif., USA
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Metabolic syndrome comprises a set of chronic diseases (hypertension, diabetes, dyslipidemia, and cardiovascular disease) that tend to cluster together. Although obesity is commonly thought to be the antecedent of metabolic syndrome, this syndrome also occurs in lean individuals, suggesting that obesity is a marker of metabolic syndrome rather than a cause. The cellular mechanisms of metabolic syndrome include mitochondrial overload, de novo lipogenesis, hepatic insulin resistance and hyperinsulinemia, reactive oxygen species formation, endoplasmic reticulum stress, and the unfolded protein response. Specific alterations of the Western Diet uniquely drive this process and are unrelated to calories. These alterations include too little fiber, omega-3 fatty acids, and micronutrients, and too many omega-6 fatty acids, trans-fats, branched-chain amino acids, ethanol, and fructose. The food industry invokes personal responsibility while denying any corporate responsibility and citing scientific, policy, and social arguments. However, their responses obfuscate the scientific truth in order to obviate their culpability.
© 2015 S. Karger AG, Basel
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.