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Original Research Article

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Are There Any Connections between Language Deficits and Cognitive Slowing in Alzheimer's Disease

Schecker M.c · Kochler C.c · Schmidtke K.b · Rauh R.a

Author affiliations

aKlinik für Psychiatrie, Psychotherapie und Psychosomatik im Kindes- und Jugendalter, Universität Freiburg, Freiburg, bKlinik für Hirnleistungsstörungen Klausenbach, Nordrach, and cNeurolinguistisches Labor NLL, Klinik für Psychiatrie, Psychotherapie und Psychosomatik im Kindes- und Jugendalter, Universität Freiburg, Freiburg, Germany

Corresponding Author

Prof. Dr. Michael Schecker

Neurolinguistisches Labor NLL, Klinik für Psychiatrie, Psychotherapie und

Psychosomatik im Kindes- und Jugendalter, Universität Freiburg

Hauptstrasse 1, DE-79104 Freiburg (Germany)

E-Mail michael.schecker@zfn-brain.uni-freiburg.de

Related Articles for ""

Dement Geriatr Cogn Disord Extra 2014;4:442-449

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Abstract

Background: Speech disorders already occur in the early phases of Alzheimer's disease (AD). As a possible cause, problems of executive processes are discussed. Cognitive slowing is also repeatedly addressed. Aims: Are there any connections between cognitive slowing and speech disorders in AD? And is there a relationship between cognitive slowing and executive processes? Methods: The data of 72 healthy controls and 52 AD patients were examined with regard to their language performance and their response times in a computerized Stroop paradigm. Results: The AD patients showed significantly worse results in all language tests as well as much longer reaction times in all Stroop conditions, especially in the interference condition (Stroop 3). Speech errors and response times correlated with severity (MMSE), and the speech errors correlated with the reaction times in Stroop 3 (interference condition, which reflects the processing time of executive processes). Conclusion: The most interesting question now is: How are language processing and executive processing time (Stroop 3) related?

© 2014 S. Karger AG, Basel


References

  1. Collette F, Van der Linden M, Salmon E: Executive dysfunction in Alzheimer's disease. Cortex 1999;35:57-72.
    External Resources
  2. Baddeley AD, Bressi S, Della Sala S, Logie R, Spinnler H: The decline of working memory in Alzheimer's disease: a longitudinal study. Brain 1991;114:2521-2542.
  3. Baddeley AD: Exploring the central executive. Q J Exp Psychol A 1996;49A:5-28.
    External Resources
  4. Toepper M, Behlo T, Thomas C, Driessen M: Early detection of Alzheimer's disease: a new working memory paradigm. Int J Geriatr Psychiatry 2008;23:272-278.
  5. Huntley JD, Howard RJ: Working memory in early Alzheimer's disease: a neuropsychological review. Int J Geriatr Psychiatry 2010;25:121-132.
  6. Almor A, Kempler D, MacDonald MC, Andersen ES, Taylor LK: Why do Alzheimer patients have difficulty with pronouns? Working memory, semantics, and reference in comprehension and production in Alzheimer's disease. Brain Lang 1999;67:202-227.
  7. Schecker M, Hentrich-Hesse T: Proformen: (Kon-)Textorganisation und Rezeptionssteuerung bei Alzheimer-Demenz; in Marillier JF, Dalmas M, Behr I (eds): Text und Sinn. Tübingen, Stauffenburg Verlag, 2005, pp 79-93.
  8. Chenery HJ, Ingram JCL, Murdoch BE: The resolution of lexical ambiguity with reference to context in dementia of the Alzheimer's type. Int J Lang Commun Disord 1998;33:393-412.
  9. Balota DA, Watson JM, Duchek JM, Ferraro FR: Cross-modal semantic and homograph priming in healthy young, healthy old, and in Alzheimer's disease individuals. J Int Neuropsychol Soc 1999;5:626-640.
    External Resources
  10. Faupel M, Maisch S, Möller G: Kontextverarbeitung bei dementiellen Syndromen; in Hock C, Hüll M, Schecker M (eds): Die Alzheimer-Krankheit. Tübingen, Narr-Verlag, 2000, pp 67-90.
  11. Papagno C, Lucchelli F, Muggia S, Rizzo S: Idiom comprehension in Alzheimer's disease: the role of the central executive. Brain 2003;126:2419-2430.
  12. Rassiga C, Lucchelli F, Crippa F, Papagno C: Ambiguous idiom comprehension in Alzheimer's disease. J Clin Exp Neuropsychol 2009;31:402-441.
  13. Rapp AM, Wild B: Nonliteral language in Alzheimer dementia: a review. J Int Neuropsychol Soc 2011;17:207-218.
  14. Binetti G, Magni E, Padovani A, Cappa SF, Bianchetti A, Trabucchi M: Executive dysfunction in early Alzheimer's disease. J Neurol Neurosurg Psychiatry 1996;60:91-93.
  15. Schecker M: Wortfindung und verbale Flüssigkeit in frühen Stadien der Alzheimer-Krankheit; in Kleiber G, Kochendörfer G, Riegel M, Schecker M (eds): Kognitive Linguistik und Neurowissenschaften. Tübingen, Narr-Verlag, 1999, pp 128-150.
  16. Bayles KA: Effects of working memory deficits on the communicative functioning of Alzheimer's dementia patients. J Commun Disord 2003;36:209-219.
  17. Stockholm J, Vogel A, Grade A, Waldemar G: Heterogeneity in executive impairment in patients with very mild Alzheimer's disease. Dement Geriatr Cogn Disord 2006;22:54-59.
  18. Schecker M: Pragmatische Sprachstörungen bei Alzheimer-Demenz / Pragmatic Language Disorders in Alzheimer's Disease. Sprache Stimme Gehör 2010;34:63-72.
    External Resources
  19. Fisher LM, Freed DM, Corkin S: Stroop Color-Word Test performance in patients with Alzheimer's disease. J Clin Exp Neuropsychol 1990;12:745-758.
  20. Nebes RD, Brady CB: Generalized cognitive slowing and severity of dementia in Alzheimer's disease: implications for the interpretation of response-time data. J Clin Exp Neuropsychol 1992;14:317-326.
  21. Spieler DH, Balota DA, Faust ME: Stroop performance in healthy younger and older adults and in individuals with dementia of the Alzheimer's type. J Exp Psychol Hum Percept Perform 1996;22:461-479.
  22. Bondi MW, Serody AB, Chan AS, Eberson-Shumate SC, Delis DC, Hansen LA, Salmon DP: Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease. Neuropsychology 2002;16:335-343.
  23. Amieva H, Rouch-Leroyer I, Letenneur L, Dartigues JF, Fabrigoule C: Cognitive slowing and learning of target detection skills in pre-demented subjects. Brain Cogn 2004;54:212-214.
  24. Saß H, Wittchen U, Zaudig M, Houben I: Diagnostisches und statistisches Manual psychischer Störungen - Textrevision - DSM-IV-TR. Hogrefe, Göttingen, 2003.
  25. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
  26. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303-308.
  27. Petersen RC: Mild cognitive impairment: current research and clinical implications. Semin Neurol 2007;27:22-31.
  28. Folstein MF, Folstein SE, McHugh PR: ‘Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
  29. Yesavage JA, Brink TL, Rose TL, Lum O, Huang VS, Adey M, Leirer VO: Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res 1983;17:37-49.
  30. Salmaso D, Longoni AM: Problems in the assessment of hand preference. Cortex 1985;21:533-549.
  31. Koss E, Ober BA, Delis DC, Friedland RP: The Stroop color-word test: indicator of dementia severity. Int J Neurosci 1984;24:53-61.
  32. ‘Jeton', Neuropsychological Therapies Petra Rigling: Reha-Service®.
  33. Kirshner HS, Webb WG, Kelly MP, Wells CE: Language disturbance. An initial symptom of cortical degenerations and dementia. Arch Neurol 1984;41:491-496.
  34. Shuttleworth EC, Huber SJ: The naming disorder of dementia of Alzheimer type. Brain and Language 1988;34:222-234.
  35. Schecker M: Prozesse der Aktivierung des mentalen Lexikons; in Schecker M: Wortfindung und Wortfindungsstörungen. Tübingen, Narr (cognitio 11), 2002, pp 109-132.
  36. Sedlmeier P: Jenseits des Signifikanztest-Rituals: Ergänzungen und Alternativen. Meth Psychol Res Online 1996;1:41-63.
  37. Schumann E: Gibt es einen Zusammenhang zwischen kognitiver Verlangsamung und Sprachdefiziten bei leichter Alzheimer-Demenz? Eine Pilotstudie; thesis, Universität Freiburg i.Br., 2008.

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Published online: November 12, 2014
Issue release date: September – December

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 5


eISSN: 1664-5464 (Online)

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