Continuous Hemodiafiltration with a Cytokine-Adsorbing Hemofilter in Patients with Septic Shock: A Preliminary ReportShiga H.a · Hirasawa H.b · Nishida O.c · Oda S.b · Nakamura M.b · Mashiko K.d · Matsuda K.e · Kitamura N.f · Kikuchi Y.a · Fuke N.a
aEmergency and Intensive Care Center, Teikyo University Chiba Medical Center, Chiba, bDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, cDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Aichi, dDepartment of Emergency and Critical Care Medicine, Nippon Medical University Chiba Hokusoh Hospital, Chiba, eDepartment of Emergency and Critical Care Medicine, University of Yamanashi School of Medicine, Yamanashi, and fDepartment of Emergency and Critical Care Medicine, Kimitsu Chuo Hospital, Chiba, Japan
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Article / Publication Details
Background/Aim: We investigated the clinical efficacy of continuous hemodiafiltration (CHDF) with AN69ST hemofilter (AN69ST-CHDF) in patients with septic shock. Materials and Methods: A prospective, multicenter, single-arm study was conducted. Patients with sepsis and shock defined by hyperlactemia were enrolled. The patients were treated with CHDF and in accordance with the Surviving Sepsis Campaign guidelines (SSCG). Results: Thirty-four patients were enrolled. On ICU admission, the mean blood IL-6 level was 44,800 ± 77,700 pg/ml, and the mean blood lactate level was 69.0 ± 49.4 mg/dl. Both the mean blood IL-6 and lactate levels had significantly decreased to normal ranges after 72 h of AN69ST-CHDF. Though the mean APACHE II score was 32.7 ± 9.8, 28-day survival was 73.5%. Conclusion: The current study suggested that adding AN69ST-CHDF to the treatments outlined in the SSCG might lead to good outcomes for patients with septic shock, probably via the removal of cytokines from the bloodstream.
© 2014 S. Karger AG, Basel
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