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Invited Review

Clinical Hepatocyte Transplantation: Practical Limits and Possible Solutions

Gramignoli R. · Vosough M. · Kannisto K. · Srinivasan R.C. · Strom S.C.

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Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

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Eur Surg Res 2015;54:162-177

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Article / Publication Details

First-Page Preview
Abstract of Invited Review

Received: September 24, 2014
Accepted: November 04, 2014
Published online: January 23, 2015
Issue release date: February 2015

Number of Print Pages: 16
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

Since the first human hepatocyte transplants (HTx) in 1992, clinical studies have clearly established proof of principle for this therapy as a treatment for patients with acquired or inherited liver disease. Although major accomplishments have been made, there are still some specific limitations to this technology, which, if overcome, could greatly enhance the efficacy and implementation of this therapy. Here, we describe what in our view are the most significant obstacles to the clinical application of HTx and review the solutions currently proposed. The obstacles of significance include the limited number and quality of liver tissues as a cell source, the lack of clinical grade reagents, quality control evaluation of hepatocytes prior to transplantation, hypothermic storage of cells prior to transplantation, preconditioning treatments to enhance engraftment and proliferation of donor cells, tracking or monitoring cells after transplantation, and the optimal immunosuppression protocols for transplant recipients.

© 2015 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Invited Review

Received: September 24, 2014
Accepted: November 04, 2014
Published online: January 23, 2015
Issue release date: February 2015

Number of Print Pages: 16
Number of Figures: 1
Number of Tables: 1

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

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