Association between Vitamin C Intake and Glioma Risk: Evidence from a Meta-AnalysisZhou S.a · Wang X.b · Tan Y.c · Qiu L.b · Fang H.b · Li W.b
aCenter of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, bDepartment of Military Nursing, School of Nursing, Third Military Medical University, Chongqing, cDepartment of Hematology, Southwest Hospital, Third Military Medical University, Chongqing, China
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Article / Publication Details
Background: The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk. Methods: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. Results: Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found. Conclusions: Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans.
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