Nitric Oxide Synthase Inhibition Abolishes Exercise-Mediated Protection against Isoproterenol-Induced Cardiac Hypertrophy in Female MiceRen J.a · Yang L.b · Tian W.b · Zhu M.c · Liu J.b · Lu P.a · Li J.b · Yang L.b · Qi Z.c
aDepartment of Parasitology, Basic Medical College, Tianjin Medical University, and Departments of bPharmacology and cHistology and Embryology, School of Medicine, Nankai University, Tianjin, China
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Objective: Exercise training (ET) provides a cardioprotective effect against pathological cardiac hypertrophy. Nitric oxide (NO) plays an important role in modulating cardiac hypertrophy. However, few studies explore the relationship between NO signaling and the inhibitory effect of ET on pathological cardiac remodeling. Methods: In this study, we evaluated ET effects on isoproterenol (ISO)-induced cardiac hypertrophy in female mice. Moreover,
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