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Clinical Study

Is Chemoradiotherapy Beneficial for Stage IV Rectal Cancer?

Huh J.W.a · Kim H.C.a · Park H.C.b · Choi D.H.b · Park J.O.c · Park Y.S.c · Park Y.A.a · Cho Y.B.a · Yun S.H.a · Lee W.Y.a · Chun H.-K.d

Author affiliations

Departments of aSurgery, bRadiation Oncology and cHematology-Oncology, Samsung Medical Center, and dDepartment of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

Related Articles for ""

Oncology 2015;89:14-22

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: November 06, 2014
Accepted: November 28, 2014
Published online: March 11, 2015
Issue release date: June 2015

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Purpose: The aim of this study was to investigate the oncologic impact of preoperative or postoperative chemoradiotherapy on stage IV rectal cancer. Methods: A total of 140 consecutive patients with locally advanced mid-to-lower rectal cancer and resectable stage IV disease were prospectively enrolled. In total, 69 patients received chemoradiotherapy (26 preoperatively and 43 postoperatively); in contrast, 71 did not. Survival curves were constructed using the Kaplan-Meier method, and a multivariate analysis was performed to identify independent prognostic factors. Results: According to the multivariate analysis, radiation therapy was not an independent factor associated with either survival or recurrence. The overall survival curves revealed that patients who underwent radiotherapy tended to have a better survival compared with patients who did not undergo radiotherapy; however, this trend was not statistically significant (p = 0.057). The disease-free, local recurrence-free, and distant metastasis-free survival curves did not differ significantly between the two groups. The local recurrence-free survival rates for patients who underwent preoperative radiotherapy were significantly higher than those for patients who underwent postoperative radiotherapy (p = 0.042). Conclusion: Preoperative radiotherapy, rather than postoperative radiotherapy, may improve local control of stage IV rectal cancer. However, chemoradiotherapy did not improve the survival of patients with stage IV rectal cancer in this study.

© 2015 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: November 06, 2014
Accepted: November 28, 2014
Published online: March 11, 2015
Issue release date: June 2015

Number of Print Pages: 9
Number of Figures: 2
Number of Tables: 5

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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