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Original Paper

BMP2 Is Associated with Caries Experience in Primary Teeth

Romanos H.F.a · Antunes L.S.c, d · Lopes L.B.c · Sabóia T.M.a · Tannure P.N.b · Lips A.c · Antunes L.A.A.d · Abreu F.V.d · Deeley K.g · Alves G.c · Granjeiro J.M.e · Vieira A.R.g · Costa M.C.a · Küchler E.C.f

Author affiliations

aDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Rio de Janeiro Federal University, and bSchool of Dentistry, Veiga de Almeida University, Rio de Janeiro, cClinical Research Unit, Fluminense Federal University, Niterói, dDepartment of Specific Formation, School of Dentistry, Fluminense Federal University, Nova Friburgo, eDirectory of Programs, National Institute of Metrology, Quality and Technology (INMETRO), Duque de Caxias, and fDepartment of Pediatric Clinic, Ribeirão Preto Dental School, USP, University of São Paulo, Ribeirão Preto, Brazil; gDepartment of Oral Biology, University of Pittsburgh, Pittsburgh, Pa., USA

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Caries Res 2015;49:425-433

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 07, 2014
Accepted: December 15, 2014
Published online: June 30, 2015
Issue release date: August 2015

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 9

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE

Abstract

Bone morphogenetic proteins (BMPs) play an important role during the initial process of enamel development and therefore may play a role in caries susceptibility. The purpose of this study was to evaluate the association between the polymorphisms in the BMP2, BMP4 and BMP7 genes and their association with caries experience and primary enamel microhardness characteristics. DNA from buccal cells as well as clinical and demographic information from 1,731 subjects from three different data sets from Brazil were included. Polymorphisms in BMP2, BMP4 and BMP7 were analyzed by real-time polymerase chain reaction from genomic DNA. Association between caries experience, genotype, and allele distribution in both cohorts was evaluated using χ2 and logistic regression analyses. In the family-based set, the association between caries experience and alleles was tested using the transmission disequilibrium test. In the Rio de Janeiro cohort, microhardness data on 108 exfoliated primary teeth before and after demineralization and remineralization challenges was included. Associations between microhardness values and genotype and allele distribution were evaluated using χ2 and logistic regression analyses. Differences between caries experience and some risk factors were statistically significant. In the cohort from Nova Friburgo, BMP2 was associated with caries experience in primary dentition during logistic regression analysis (p = 0.023; OR = 2.58; 95% CI 1.13-5.86). There was no association between genotype and allele distribution for BMP polymorphisms and primary enamel microhardness alterations. Our result suggests that BMP2 may be involved in caries experience in primary dentition from a Nova Friburgo cohort.

© 2015 S. Karger AG, Basel


References

  1. Aberg T, Wozney J, Thesleff I: Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation. Dev Dyn 1997;210:383-396.
  2. Boraas JC, Messer LB, Till MJ: A genetic contribution to dental caries, occlusion, and morphology as demonstrated by twins reared apart. J Dent Res 1988;67:1150-1155.
  3. Bretz WA, Corby PM, Schork NJ, Robinson MT, Coelho M, Costa S, Melo Filho MR, Weyant RJ, Hart TC: Longitudinal analysis of heritability for dental caries traits. J Dent Res 2005;84:1047-1051.
  4. Conry JP, Messer LB, Boraas JC, Aeppli DP, Bouchard TJ Jr: Dental caries and treatment characteristics in human twins reared apart. Arch Oral Biol 1993;38:937-943.
  5. Dean M: Approaches to identify genes for complex human diseases: lessons from Mendelian disorders. Hum Mutat 2003;22:261-274.
  6. Deeley K, Letra A, Rose EK, Brandon CA, Resick JM, Marazita ML, Vieira AR: Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population. Caries Res 2008;42:8-13.
  7. de Souza JM, Arrillaga AN, Ochoa FV, Rocha O: Prevalence of dental caries in whites and non-whites. Rev Saúde Pública 1967;1:38-43.
  8. Feng J, Yang G, Yuan G, Gluhak-Heinrich J, Yang W, Wang L, Chen Z, Schulze McDaniel J, Donly KJ, Harris SE, Macdougall M, Chen S: Abnormalities in the enamel in bmp2-deficient mice. Cells Tissues Organs 2011;194:216-221.
  9. Hogan BL: Bmps: multifunctional regulators of mammalian embryonic development. Harvey Lect 1996;92:83-98.
  10. Hunt HR, Hoppert CA: Inheritance of susceptibility to dental caries in rats (Mus norwegicus). Genetics 1946;31:219.
  11. Huq NL, Cross KJ, Ung M, Reynolds EC: A review of protein structure and gene organisation for proteins associated with mineralised tissue and calcium phosphate stabilisation encoded on human chromosome 4. Arch Oral Biol 2005;50:599-609.
  12. Jindal A, McMeans M, Narayanan S, Rose EK, Jain S, Marazita ML, Menezes R, Letra A, Carvalho FM, Brandon CA, Resick JM, Mereb JC, Poletta FA, Lopez-Camelo JS, Castilla EE, Orioli IM, Vieira AR: Women are more susceptible to caries but individuals born with clefts are not. Int J Dent 2011;2011:454532.
  13. Kang SW, Yoon I, Lee HW, Cho J: Association between AMELX polymorphisms and dental caries in Koreans. Oral Dis 2010;17:399-406.
  14. Küchler EC, Tannure PN, Falagan-Lotsch P, Lopes TS, Granjeiro JM, Amorim LM: Buccal cells DNA extraction to obtain high quality human genomic DNA suitable for polymorphism genotyping by PCR-RFLP and real-time PCR. J Appl Oral Sci 2012;20:467-471.
  15. Maestrini E, Marlow AJ, Weeks DE, Monaco AP: Molecular genetic investigations of autism. J Autism Dev Disord 1998;28:427-437.
  16. Miyoshi K, Nagata H, Horiguchi T, Abe K, Arie Wahyudi I, Baba Y, Harada H, Noma T: BMP2-induced gene profiling in dental epithelial cell line. J Med Invest 2008;55:216-226.
  17. Nohno T, Kawakami Y, Ohuchi H, Fujiwara A, Yoshioka H, Noji S: Involvement of the Sonic hedgehog gene in chick feather formation. Biochem Biophys Res Commun 1995;206:33-39.
  18. Olszowski T, Adler G, Janiszewska-Olszowska J, Safranow K, Kaczmarczyk M: MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children. Oral Dis 2012;18:389-395.
  19. Patir A, Seymen F, Yildirim M, Deeley K, Cooper ME, Marazita ML, Vieira AR: Enamel formation genes are associated with high caries experience in Turkish children. Caries Res 2008;42:394-400.
  20. Queiroz CS, Hara AT, Paes Leme AF, Cury JA: pH-cycling models to evaluate the effect of low fluoride dentifrice on enamel de- and remineralization. Braz Dent J 2008;19:21-27.
  21. Ranade K, Chang MS, Ting CT, Pei D, Hsiao CF, Olivier M, Pesich R, Hebert J, Chen YD, Dzau VJ, Curb D, Olshen R, Risch N, Cox DR, Botstein D: High-throughput genotyping with single nucleotide polymorphisms. Genome Res 2001;11:1262-1268.
  22. Shimizu T, Ho B, Deeley K, Briseno-Ruiz J, Faraco IM Jr, Schupack BI, Brancher JA, Pecharki GD, Kuchler EC, Tannure PN, Lips A, Vieira TC, Patir A, Yildirim M, Poletta FA, Mereb JC, Resick JM, Brandon CA, Orioli IM, Castilla EE, Marazita ML, Seymen F, Costa MC, Granjeiro JM, Trevilatto PC, Vieira AR: Enamel formation genes influence enamel microhardness before and after cariogenic challenge. PLoS One 2012;7:e45022.
  23. Tannure PN, Costa Mde C, Küchler EC, Romanos HF, Granjeiro JM, Vieira AR: Caries experience in individuals with cleft lip and palate. Pediatr Dent 2012a;34:127-131.
  24. Tannure PN, Küchler EC, Falagan-Lotsch P, Amorim LM, Raggio Luiz R, Costa MC, Vieira AR, Granjeiro JM: MMP13 polymorphism decreases risk for dental caries. Caries Res 2012b;46:401-407.
  25. Tannure PN, Küchler EC, Lips A, Costa Mde C, Luiz RR, Granjeiro JM, Vieira AR: Genetic variation in MMP20 contributes to higher caries experience. J Dent 2012c;40:381-386.
  26. Thesleff I: Developmental biology and building a tooth. Quintessence Int 2003;34:613-620.
  27. Thesleff I, Vaahtokari A, Kettunen P, Aberg T: Epithelial-mesenchymal signaling during tooth development. Connect Tissue Res 1995;32:9-15.
  28. Thomadakis G, Ramoshebi LN, Crooks J, Rueger DC, Ripamonti U: Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures. Eur J Oral Sci 1999;107:368-377.
  29. Touger-Decker R, van Loveren C: Sugars and dental caries. Am J Clin Nutr 2003;78:881S-892S.
  30. Vaahtokari A, Aberg T, Jernvall J, Keranen S, Thesleff I: The enamel knot as a signaling center in the developing mouse tooth. Mech Dev 1996;54:39-43.
  31. Vainio S, Karavanova I, Jowett A, Thesleff I: Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell 1993;75:45-58.
  32. Vieira AR, Marazita ML, Goldstein-McHenry T: Genome-wide scan finds suggestive caries loci. J Dent Res 2008;87:435-439.
  33. Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Werner S, Thesleff I: Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell 2004;7:719-730.
  34. Wharton K, Derynck R: TGFbeta family signaling: novel insights in development and disease. Development 2009;136:3691-3697.
  35. WHO: Oral Health Surveys: Basic Methods. Geneva, World Health Organization, 1997.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 07, 2014
Accepted: December 15, 2014
Published online: June 30, 2015
Issue release date: August 2015

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 9

ISSN: 0008-6568 (Print)
eISSN: 1421-976X (Online)

For additional information: https://www.karger.com/CRE


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