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Original Paper

Demographic, Hematologic, and Clinical Features of Myelodysplastic Syndrome Patients: Results from the First Polish Myelodysplastic Syndrome Registry

Mądry K.a · Machowicz R.a · Waszczuk-Gajda A.a · Drozd-Sokołowska J.a · Hołowiecka B.S.e · Wiater E.a · Mital A.f · Obara A.g · Szmigielska-Kapłon A.h · Kołkowska-Leśniak A.b · Sikorska A.b · Subocz E.c · Mendrek W.e · Szczepańska M.i · Biedroń M.j · Jachalska A.k · Wasilewska E.l · Wojciechowska M.m · Guzicka-Kazimierczak R.n · Kopacz A.o · Katinas K.p · Kruger W.p · Dawidowska A.d · Salamańczuk Z.q · Zawirska D.q · Świderska A.r · Jędrzejczak W.W.a · Dwilewicz-Trojaczek J.a

Author affiliations

aDepartment of Hematology, Oncology, Internal Medicine and Bone Marrow Transplantation, Medical University of Warsaw, bDepartment of Hematology, Institute of Hematology and Transfusiology, cDepartment of Hematology and Internal Diseases, Military Institute of Medicine, and dDepartment of Oncology and Hematology, Central Clinical Hospital of the Ministry of Interior, Warsaw, eDepartment of Haematology and Bone Marrow Transplantation, Silesian Medical University, Katowice, fDepartment of Hematology and Bone Marrow Transplantation, Medical University of Gdańsk, Gdańsk, gDepartment of Hematology, Holycross Cancer Center, Kielce, hDepartment of Hematology, Medical University of Łódź, Łódź, iNicolaus Copernicus Specialist Municipal Hospital, Toruń, jDepartment and Clinic of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wrocław Medical University, Wrocław, kDepartment of Hematology, Medical University of Bydgoszcz, Bydgoszcz, lDepartment of Hematology, Medical University of Białystok, Białystok, mDepartment of Hematology, Regional Specialist Hospital, Olsztyn, nDepartment of Hematology, Pomeranian Medical University, Szczecin, oDepartment of Hematology, Voivodal Specialistic Hospital, Rzeszów, pDepartment of Internal Medicine, J. Strus Hospital, Poznań, qDepartment of Hematology, Jagiellonian University, Kraków, and rDepartment of Hematology, Provincial Hospital, Zielona Góra, Poland

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Acta Haematol 2015;134:125-134

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2014
Accepted: January 09, 2015
Published online: April 24, 2015
Issue release date: July 2015

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 4

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA

Abstract

Epidemiological studies on myelodysplastic syndromes (MDS) in Middle-Eastern Europe are scarce. No data about the demographic, clinical, and laboratory features of Polish MDS patients have been published. The aim of this study was to assess the epidemiological data and toxic exposure of Polish MDS patients and their association with hematological parameters and clinical outcomes. For 15 months, 966 living MDS patients were enrolled at 24 centers (12 university and 12 community hospitals). Follow-up was conducted for the next 55 months. The percentage of patients older than 80 years (16%) was between the values for Eastern and Western countries. In patients younger than 55 years, a female predominance was observed (male/female ratio 0.70:1 vs. 1.29:1; p < 0.001). Female patients had higher platelet counts (160 × 109/l vs. 111 × 109/l; p < 0.001). Patients exposed to chemicals were younger than patients without such exposure; their median age at MDS diagnosis was 66 vs. 70 years (p = 0.037). Smokers had significantly lower hemoglobin concentrations (8.6 vs. 9.1 g/dl; p = 0.032) and lower platelet counts (99 × 109/l vs. 137 × 109/l; p < 0.001) than nonsmokers. We provide the first description of the characteristics of Polish MDS patients. Females predominated in the group aged <60 years and they had higher platelet counts. The course of the disease is affected by toxic exposure and smoking.

© 2015 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 28, 2014
Accepted: January 09, 2015
Published online: April 24, 2015
Issue release date: July 2015

Number of Print Pages: 10
Number of Figures: 2
Number of Tables: 4

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: https://www.karger.com/AHA


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