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Review

Reactive Oxygen Species in Psoriasis and Psoriasis Arthritis: Relevance to Human Disease

Khmaladze I. · Nandakumar K.S. · Holmdahl R.

Author affiliations

Division of Medical Inflammation Research, Department of Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Corresponding Author

Correspondence to: Prof. Rikard Holmdahl

Division of Medical Inflammation Research

Department of Medical Biochemistry and Biophysics, Karolinska Institutet

SE-171 77 Stockholm (Sweden)

E-Mail rikard.holmdahl@ki.se

Related Articles for ""

Int Arch Allergy Immunol 2015;166:135-149

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Abstract

Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psoriasis arthritis (PsA). Animal models that reflect the typical Ps syndrome, including both skin and joint pathology as in Ps and PsA, are valuable tools for dissecting disease pathways leading to clinical manifestations. In this context, we developed a new acute Ps and PsA-like disease model that appears after exposure to Saccharomyces cerevisiae mannan in certain mouse strains. The disease was found to be triggered by mannan-activated macrophages, leading to the activation of a pathogenic interleukin-17 pathway involving innate lymphocytes. Interestingly, the production of reactive oxygen species protected the mice from the triggering of this pathway and ameliorated Ps and PsA development.

© 2015 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: March 20, 2015
Issue release date: April 2015

Number of Print Pages: 15
Number of Figures: 4
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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