Translational Thyroidology / Original Paper
Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and HyperthyroidismEngels K.a · Rakov H.a · Zwanziger D.a · Moeller L.C.a · Homuth G.b · Köhrle J.c · Brix K.d · Führer D.a
aDepartment of Endocrinology and Metabolism, University Hospital Essen, Essen, bDepartment of Functional Genomics, Ernst-Moritz-Arndt University Greifswald, Greifswald, cInstitute of Experimental Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, and dDepartment of Life Sciences and Chemistry, Jacobs University Bremen, Bremen, Germany
Dagmar Führer, MD, PhD
Department of Endocrinology and Metabolism and Division of Laboratory Research
University Hospital Essen, Hufelandstrasse 55
DE-45147 Essen (Germany)
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Background: Clinical features of thyroid dysfunction vary with age, and an oligosymptomatic presentation of hyperthyroidism is frequently observed in the elderly. This suggests age modulation of thyroid hormone (TH) action, which may occur, for example, by alterations in TH production, metabolism and/or TH action in target organs. Objectives: In this paper, we address possible changes in TH transporter expression in liver tissues as a mechanism of age-dependent variation in TH action. Methods: Chronic hyperthyroidism was induced in 4- and 20-month-old C57BL6/NTac male mice (n = 8-10) by intraperitoneal injections of 1 µg/g body weight
© 2015 European Thyroid Association Published by S. Karger AG, Basel
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