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Letter to the Editor

Open Access Gateway

Concerning Sichieri R, Cunha DB: Obes Facts 2014;7:221-232. The Assertion that Controlling for Baseline (Pre-Randomization) Covariates in Randomized Controlled Trials Leads to Bias Is False

Li P.a · Brown A.W.a · Dawson J.A.a · Kaiser K.A.a · Bohan Brown M.M.b · Keith S.W.c · Oakes J.M.d · Allison D.B.a

Author affiliations

aOffice of Energetics and Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, AL, USA; bDepartment of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, SC, USA; cDivision of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA; dDivision of Epidemiology and Minnesota Population Center, University of Minnesota, Minneapolis, MN, USA

Corresponding Author

David B. Allison, Ph.D.

Office of Energetics and Nutrition Obesity Research Center

University of Alabama at Birmingham, Ryals Building, Room 140J

1665 University Boulevard, Birmingham, Alabama 35294, USA


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Obes Facts 2015;8:127-129

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Abstract of Letter to the Editor


  1. Sichieri R, Cunha DB: Unbalanced baseline in school-based interventions to prevent obesity: adjustment can lead to bias - a systematic review. Obes Facts 2014;7:221-232.
  2. Crespi CM, Maxwell AE, Wu S: Cluster randomized trials of cancer screening interventions: are appropriate statistical methods being used? Contemp Clin Trials 2011;32:477-484.
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    External Resources
  4. Allison DB: When is it worth measuring a covariate in a randomized clinical trial? J Consult Clin Psychol 1995;63:339-343.
  5. Lazar AA, Zerbe GO: Solutions for determining the significance region using the Johnson-Neyman type procedure in generalized linear (mixed) models. J Educ Behav Stat 2011;36:699-719.
  6. Moerbeek M: Power and money in cluster randomized trials: when is it worth measuring a covariate? Stat Med 2006;25:2607-2617.
  7. Chan SF, Macaskill P, Irwig L, Walter SD: Adjustment for baseline measurement error in randomized controlled trials induces bias. Control Clin Trials 2004;25:408-416.
  8. Fitzmaurice GM, Laird NM, Ware JH: Applied Longitudinal Analysis. Hoboken, Wiley, 2011.
  9. Hannan, PJ: Experimental social epidemiology: controlled community trials; in Oakes JM, Kaufman JS (eds): Methods in Social Epidemiology. San Francisco, Jossey-Bass / Wiley, 2006, pp 335-364.
  10. Story M, Hannan PJ, Fulkerson JA, Rock BH, Smyth M, Arcan C, Himes JH: Bright Start: description and main outcomes from a group-randomized obesity prevention trial in American Indian children. Obesity (Silver Spring) 2012;20:2241-2249.

Article / Publication Details

Received: September 24, 2014
Accepted: October 22, 2014
Published online: April 02, 2015
Issue release date: April 2015

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1662-4025 (Print)
eISSN: 1662-4033 (Online)

For additional information: https://www.karger.com/OFA

Open Access License / Drug Dosage / Disclaimer

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