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Clinical Thyroidology / Original Paper

Free Access

Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling

Dietrich J.W.a · Müller P.b, d · Schiedat F.b · Schlömicher M.c · Strauch J.c · Chatzitomaris A.a · Klein H.H.a · Mügge A.b · Köhrle J.e · Rijntjes E.e · Lehmphul I.e

Author affiliations

aDepartment of Endocrinology and Diabetes, Medical Hospital I, bDepartment of Cardiology and Angiology, Medical Hospital II, and cDepartment of Cardiac Surgery, Bergmannsheil University Hospitals, Ruhr University of Bochum, Bochum, dHeart Center Bad Neustadt, Clinic for Interventional Electrophysiology, Bad Neustadt an der Saale, and eInstitut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany

Corresponding Author

Dr. Johannes W. Dietrich

Department of Endocrinology and Diabetes, Medical Hospital I

Bergmannsheil University Hospitals, Ruhr University of Bochum

Bürkle-de-la-Camp-Platz 1, DE-44789 Bochum (Germany)

E-Mail johannes.dietrich@ruhr-uni-bochum.de

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Eur Thyroid J 2015;4:129-137

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Background: Although hyperthyroidism predisposes to atrial fibrillation, previous trials have suggested decreased triiodothyronine (T3) concentrations to be associated with postoperative atrial fibrillation (POAF). Therapy with thyroid hormones (TH), however, did not reduce the risk of POAF. This study reevaluates the relation between thyroid hormone status, atrial electromechanical function and POAF. Methods: Thirty-nine patients with sinus rhythm and no history of atrial fibrillation or thyroid disease undergoing cardiac surgery were prospectively enrolled. Serum concentrations of thyrotropin, free (F) and total (T) thyroxine (T4) and T3, reverse (r)T3, 3-iodothyronamine (3-T1AM) and 3,5-diiodothyronine (3,5-T2) were measured preoperatively, complemented by evaluation of echocardiographic and electrophysiological parameters of cardiac function. Holter-ECG and telemetry were used to screen for POAF for 10 days following cardiac surgery. Results: Seven of 17 patients who developed POAF demonstrated nonthyroidal illness syndrome (NTIS; defined as low T3 and/or low T4 syndrome), compared to 2 of 22 (p < 0.05) patients who maintained sinus rhythm. In patients with POAF, serum FT3 concentrations were significantly decreased, but still within their reference ranges. 3,5-T2 concentrations directly correlated with rT3 concentrations and inversely correlated with FT3 concentrations. Furthermore, 3,5-T2 concentrations were significantly elevated in patients with NTIS and in subjects who eventually developed POAF. In multivariable logistic regression FT3, 3,5-T2, total atrial conduction time, left atrial volume index and Fas ligand were independent predictors of POAF. Conclusion: This study confirms reduced FT3 concentrations in patients with POAF and is the first to report on elevated 3,5-T2 concentrations in cardiac NTIS. The pathogenesis of NTIS therefore seems to involve more differentiated allostatic mechanisms.

© 2015 European Thyroid Association Published by S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Clinical Thyroidology / Original Paper

Received: December 08, 2014
Accepted: March 10, 2015
Published online: May 23, 2015
Issue release date: June 2015

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 3

ISSN: 2235-0640 (Print)
eISSN: 2235-0802 (Online)

For additional information: https://www.karger.com/ETJ

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