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Experimental Section / Original Paper

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Comprehensive Analysis of Large Sets of Age-Related Physiological Indicators Reveals Rapid Aging around the Age of 55 Years

Lixie E. · Edgeworth J. · Shamir L.

Author affiliations

Lawrence Technological University, Southfield, Mich., USA

Corresponding Author

Lior Shamir

Lawrence Technological University

21000 West Ten Mile Road

Southfield, MI 48075 (USA)

E-Mail lshamir@mtu.edu

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Gerontology 2015;61:526-533

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Background: While many studies show a correlation between chronological age and physiological indicators, the nature of this correlation is not fully understood. Objective: To perform a comprehensive analysis of the correlation between chronological age and age-related physiological indicators. Method: Physiological aging scores were deduced using principal component analysis from a large dataset of 1,227 variables measured in a cohort of 4,796 human subjects, and the correlation between the physiological aging scores and chronological age was assessed. Results: Physiological age does not progress linearly or exponentially with chronological age: a more rapid physiological change is observed around the age of 55 years, followed by a mild decline until around the age of 70 years. Conclusion: These findings provide evidence that the progression of physiological age is not linear with that of chronological age, and that periods of mild change in physiological age are separated by periods of more rapid aging.

© 2015 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Experimental Section / Original Paper

Received: March 02, 2015
Accepted: March 11, 2015
Published online: May 07, 2015
Issue release date: October 2015

Number of Print Pages: 8
Number of Figures: 9
Number of Tables: 2

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

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